Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB4A | P04350 | 2/20 | 0.51 |
| ▸ | TUBB | P07437 | 2/20 | 0.51 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.51 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.51 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.51 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.51 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.51 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.51 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.51 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.51 |
| ▸ | TUBA1A | Q71U36 | 2/20 | 0.51 |
| ▸ | TUBA1C | Q9BQE3 | 2/20 | 0.51 |
| ▸ | TUBB6 | Q9BUF5 | 2/20 | 0.51 |
| ▸ | TUBB2B | Q9BVA1 | 2/20 | 0.51 |
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6129706 | 1.00 | TUBB4A (0.51) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL6129716 | 0.86 | PTGS2 (0.47) | PTGS2MAOAMAOB | |
| SCHEMBL6129710 | 0.86 | PTGS2 (0.47) | PTGS2 | |
| SCHEMBL6129711 | 0.86 | PTGS2 (0.47) | PTGS2 | |
| SCHEMBL6129715 | 0.86 | PTGS2 (0.47) | PTGS2MAOAMAOB | |
| SCHEMBL6129703 | 0.85 | PTGS2 (0.46) | PTGS2 | |
| SCHEMBL6129717 | 0.85 | PTGS2 (0.46) | MEN1NPC1RAB9AKMT2APTGS2 | |
| SCHEMBL6129719 | 0.85 | PTGS2 (0.46) | MEN1NPC1RAB9AKMT2APTGS2 | |
| SCHEMBL6129701 | 0.85 | PTGS2 (0.46) | PTGS2 | |
| SCHEMBL6129708 | 0.83 | PTGS2 (0.50) | PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1191929-A4 | (Z)-STYRYL ACETOXYPHENYL SULFIDES AS CYCLOOXYGENASE INHIBITORS | UNIV TEMPLE (US) | 2005-02-16 | — | — | EP | disclosed |
| US-6656968-B1 | Selectively inhibit the cyclooxygenase activity of COX-2 over COX-1; addition polymers of compound | TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2003-12-02 | — | — | US | disclosed |
| EP-1191929-A2 | (Z)-STYRYL ACETOXYPHENYL SULFIDES AS CYCLOOXYGENASE INHIBITORS | Temple University of the Commonwealth System of Higher Education (US) | 2002-04-03 | — | — | EP | disclosed |
| WO-2000077169-A2 | (Z)-STYRYL ACETOXYPHENYL SULFIDES AS CYCLOOXYGENASE INHIBITORS | TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2000-12-21 | — | — | WO | disclosed |