Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | PKM | P14618 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | TGM2 | P21980 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | CCR6 | P51684 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.31 |
| ▸ | CGAS | Q8N884 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29161382 | 0.72 | MAPT (0.54) | MAPTALDH1A1KMT2AMEN1PKM | |
| SCHEMBL5855550 | 0.68 | MAPT (0.40) | MAPTALDH1A1KMT2AMEN1PKM | |
| SCHEMBL1137916 | 0.68 | MAPT (0.40) | MAPTALDH1A1KMT2AMEN1PKM | |
| Isatin SCHEMBL7073534 | 0.68 | MAPT (0.47) | MAPTALDH1A1KMT2AMEN1PKM | |
| SCHEMBL9139763 | 0.68 | ATM (0.41) | MAPTALDH1A1KMT2AMEN1PKM | |
| SCHEMBL6660995 | 0.68 | MAPT (0.37) | MAPTALDH1A1KMT2AMEN1PKM | |
| SCHEMBL317892 | 0.67 | MAPT (0.40) | MAPTALDH1A1KMT2AMEN1PKM | |
| Isatin SCHEMBL30956357 | 0.67 | MAPT (0.46) | MAPTALDH1A1KMT2AMEN1PKM | |
| SCHEMBL6866011 | 0.67 | IDO1 (0.39) | MAPTALDH1A1KMT2AMEN1PKM | |
| Hydrochloric Acid SCHEMBL28409932 | 0.67 | MAPT (0.39) | MAPTALDH1A1KMT2AMEN1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105481752-B | A kind of preparation method of the trifluoromethyl oxidized indole compounds of 3 fluorine alkenyl Oxoindole spiral shell 3,3 ' | 四川理工学院 | 2018-01-02 | — | — | CN | claimed |
| EP-1330426-A4 | SELECTIVE MAXI-K- POTASSIUM CHANNEL OPENERS FUNCTIONAL UNDER CONDITIONS OF HIGH INTRACELLULAR CALCIUM CONCENTRATION, METHODS AND USES THEREOF | BRISTOL MYERS SQUIBB CO (US) | 2005-09-14 | — | — | EP | claimed |
| CN-1469739-A | Method for modulating bladder function | — | 2004-01-21 | — | — | CN | claimed |
| EP-1363624-A2 | FLUORO OXINDOLE DERIVATIVES AS MODULATORS OF KCNQ POTASSIUM CHANNELS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-11-26 | — | — | EP | claimed |
| EP-1330426-A1 | SELECTIVE MAXI-K- POTASSIUM CHANNEL OPENERS FUNCTIONAL UNDER CONDITIONS OF HIGH INTRACELLULAR CALCIUM CONCENTRATION, METHODS AND USES THEREOF | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-07-30 | — | — | EP | claimed |
| WO-2002066426-A2 | FLUORO OXINDOLE DERIVATIVES AS MODULATORS OF KCNQ POTASSIUM CHANNELS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-08-29 | — | — | WO | claimed |
| WO-2002030868-A1 | SELECTIVE MAXI-K- POTASSIUM CHANNEL OPENERS FUNCTIONAL UNDER CONDITIONS OF HIGH INTRACELLULAR CALCIUM CONCENTRATION, METHODS AND USES THEREOF | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-04-18 | — | — | WO | claimed |
| CN-1076348-C | 3-ketoindole derivates taken as potassium channels regulator | BRISTOL MYERS SQUIBB CO LTD (US) | 2001-12-19 | — | — | CN | claimed |
| CN-1144800-A | 3-ketoindole derivates taken as potassium channels regulator | BRISTOL MYERS SQUIBB CO (US) | 1997-03-12 | — | — | CN | claimed |
| CN-114105978-A | Oxindole compound and preparation method and application thereof | 江西师范大学 | 2022-03-01 | — | — | CN | disclosed |
| CN-108047119-A | 3- fluorine alkenyl Oxoindole -3- trifluoromethyl Oxoindole compounds and its application | 四川理工学院 | 2018-05-18 | — | — | CN | disclosed |
| CN-107840818-A | Fluorine-containing titanium dioxide benzazolyl compounds and its application | 四川理工学院 | 2018-03-27 | — | — | CN | disclosed |
| CN-105481752-B | A kind of preparation method of the trifluoromethyl oxidized indole compounds of 3 fluorine alkenyl Oxoindole spiral shell 3,3 ' | 四川理工学院 | 2018-01-02 | — | — | CN | disclosed |
| CN-1287781-C | Application of KCNQ potassium channel agonist in preparing medicines for inducing or maintaining bladder function | WYETH CORP (US) | 2006-12-06 | — | — | CN | disclosed |
| WO-2002072088-A2 | MODULATORS OF KCNQ POTASSIUM CHANNELS AND USE THEREOF IN TREATING MIGRAINE AND MECHANISTICALLY RELATED DISEASES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-09-19 | — | — | WO | disclosed |
| WO-2002066426-A2 | FLUORO OXINDOLE DERIVATIVES AS MODULATORS OF KCNQ POTASSIUM CHANNELS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-08-29 | — | — | WO | disclosed |
| WO-2002000217-A1 | USE OF 3-SUBSTITUTED OXINDOLE DERIVATIVES AS KCNQ POTASSIUM CHANNEL MODULATORS | NEUROSEARCH A/S (DK) | 2002-01-03 | — | — | WO | disclosed |
| CN-1076348-C | 3-ketoindole derivates taken as potassium channels regulator | BRISTOL MYERS SQUIBB CO LTD (US) | 2001-12-19 | — | — | CN | disclosed |
| CN-1144800-A | 3-ketoindole derivates taken as potassium channels regulator | BRISTOL MYERS SQUIBB CO (US) | 1997-03-12 | — | — | CN | disclosed |
| US-5565483-A | ADMINISTERING AS THERAPY FOR ISCHEMIA, CONVULSIONS OR ASTHMA | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-10-15 | — | — | US | disclosed |