Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.82 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.82 |
| ▸ | POLB | P06746 | 8/20 | 0.82 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.82 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.82 |
| ▸ | LMNA | P02545 | 7/20 | 0.82 |
| ▸ | HPGD | P15428 | 6/20 | 0.82 |
| ▸ | RAB9A | P51151 | 6/20 | 0.82 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.82 |
| ▸ | CDC25B | P30305 | 4/20 | 0.82 |
| ▸ | CDC25A | P30304 | 3/20 | 0.82 |
| ▸ | BLM | P54132 | 2/20 | 0.82 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.82 |
| ▸ | GMNN | O75496 | 1/20 | 0.82 |
| ▸ | TP53 | P04637 | 1/20 | 0.82 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.82 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.82 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.82 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.82 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.82 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL571557 | 0.91 | MAPT (1.00) | MAPTALDH1A1POLBKDM4ESMN1; SMN2 | |
| SCHEMBL29545010 | 0.91 | MAPT (1.00) | MAPTALDH1A1POLBKDM4ESMN1; SMN2 | |
| Anthraquinone SCHEMBL9174151 | 0.80 | MEN1 (0.75) | MAPTALDH1A1POLBKDM4ESMN1; SMN2 | |
| SCHEMBL3414838 | 0.79 | CDC25B (1.00) | MAPTALDH1A1POLBKDM4ESMN1; SMN2 | |
| SCHEMBL30002742 | 0.79 | CDC25B (1.00) | MAPTALDH1A1POLBKDM4ESMN1; SMN2 | |
| SCHEMBL16138414 | 0.78 | MAPT (0.75) | MAPTALDH1A1POLBKDM4ESMN1; SMN2 | |
| SCHEMBL10901421 | 0.78 | MAPT (0.75) | MAPTALDH1A1POLBKDM4ESMN1; SMN2 | |
| SCHEMBL8285443 | 0.76 | MAPT (0.71) | MAPTALDH1A1POLBKDM4ESMN1; SMN2 | |
| SCHEMBL9562528 | 0.76 | MAPT (0.71) | MAPTALDH1A1POLBKDM4ESMN1; SMN2 | |
| SCHEMBL1436501 | 0.76 | MAPT (0.71) | MAPTALDH1A1POLBKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1450810-A4 | XANTHINE OXIDASE INHIBITION | UAB RESEARCH FOUNDATION (US) | 2005-11-30 | — | — | EP | disclosed |
| EP-1450810-A2 | XANTHINE OXIDASE INHIBITION | THE UAB RESEARCH FOUNDATION (US) | 2004-09-01 | — | — | EP | disclosed |
| US-20030158213-A1 | Xanthine oxidase inhibition as a strategy to alleviate oxidative impairment of vascular function | THE UAB RESEARCH FOUNDATION | 2003-08-21 | — | — | US | disclosed |
| WO-2003043573-A2 | XANTHINE OXIDASE INHIBITION | THE UAB RESEARCH FOUNDATION (US) | 2003-05-30 | — | — | WO | disclosed |