Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 9/20 | 0.69 |
| ▸ | CA2 | P00918 | 9/20 | 0.69 |
| ▸ | CA9 | Q16790 | 8/20 | 0.69 |
| ▸ | CA12 | O43570 | 6/20 | 0.69 |
| ▸ | MAPT | P10636 | 7/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.61 |
| ▸ | MEN1 | O00255 | 4/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.61 |
| ▸ | GAA | P10253 | 3/20 | 0.61 |
| ▸ | NPC1 | O15118 | 3/20 | 0.61 |
| ▸ | RAB9A | P51151 | 3/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.56 |
| ▸ | CA7 | P43166 | 2/20 | 0.52 |
| ▸ | CA4 | P22748 | 1/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.51 |
| ▸ | LOX | P28300 | 1/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6130732 | 1.00 | CA1 (0.69) | CA1CA2CA9CA12MAPT | |
| SCHEMBL3067386 | 0.78 | MAPT (0.64) | CA1CA2CA9CA12MAPT | |
| SCHEMBL3067385 | 0.78 | MAPT (0.64) | CA1CA2CA9CA12MAPT | |
| SCHEMBL11545508 | 0.77 | MAPT (0.59) | MAPTKMT2AMEN1SMN1; SMN2GAA | |
| SCHEMBL11544435 | 0.77 | GAA (0.56) | MAPTKMT2AMEN1SMN1; SMN2GAA | |
| SCHEMBL11545504 | 0.77 | MAPT (0.59) | MAPTKMT2AMEN1SMN1; SMN2GAA | |
| SCHEMBL11544430 | 0.77 | GAA (0.56) | MAPTKMT2AMEN1SMN1; SMN2GAA | |
| SCHEMBL4639339 | 0.71 | KMT2A (0.61) | CA1CA2CA9CA12MAPT | |
| SCHEMBL4639340 | 0.71 | KMT2A (0.61) | CA1CA2CA9CA12MAPT | |
| SCHEMBL4638913 | 0.71 | CA2 (0.79) | CA1CA2CA9CA12MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1476149-A4 | SUBSTITUTED HYDRAZONES AS INHIBITORS OF CYCLOOXYGENASE-2 | UNIV TEMPLE (US) | 2005-09-14 | — | — | EP | disclosed |
| EP-1476149-A2 | SUBSTITUTED HYDRAZONES AS INHIBITORS OF CYCLOOXYGENASE-2 | Temple University of the Commonwealth System of Higher Education (US) | 2004-11-17 | — | — | EP | disclosed |
| US-20030187035-A1 | Substituted hydrazones as inhibitors of cyclooxygenase-2 | TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2003-10-02 | — | — | US | disclosed |
| WO-2003049698-A2 | SUBSTITUTED HYDRAZONES AS INHIBITORS OF CYCLOOXYGENASE-2 | TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2003-06-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030187035-A1 | Substituted hydrazones as inhibitors of cyclooxygenase-2 | PTGS1, PTGS2, PTGES2 | CA1 211/4885CA2 136/4885CA9 523/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.