Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.32 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.32 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.31 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.31 |
| ▸ | PTGFR | P43088 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | LCK | P06239 | 1/20 | 0.31 |
| ▸ | PPARD | Q03181 | 1/20 | 0.31 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.31 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.31 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.30 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL6131721 | 0.82 | GPR84 (0.33) | GPR84FFAR1FFAR4PTGER2TBXA2R | |
| SCHEMBL4941960 | 0.80 | GUSB (0.33) | — | |
| Bicarbonate SCHEMBL6131713 | 0.78 | — | — | |
| SCHEMBL939728 | 0.76 | GPR84 (0.34) | GPR84 | |
| Bicarbonate SCHEMBL6131726 | 0.75 | FDPS (0.37) | GPR84FFAR1FFAR4PTGER2TBXA2R | |
| Bicarbonate SCHEMBL6131712 | 0.75 | GPR84 (0.33) | GPR84FFAR1FFAR4PTGER2TBXA2R | |
| SCHEMBL15299924 | 0.74 | GPR84 (0.41) | GPR84FFAR1FFAR4EPHX2MAPT | |
| SCHEMBL818393 | 0.74 | GPR84 (0.41) | GPR84FFAR1FFAR4EPHX2MAPT | |
| SCHEMBL15299921 | 0.74 | GPR84 (0.41) | GPR84FFAR1FFAR4EPHX2MAPT | |
| SCHEMBL15299834 | 0.74 | GPR84 (0.41) | GPR84FFAR1FFAR4EPHX2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0680096-B1 | Solar cell module | CANON KK (JP) | 2005-01-26 | — | — | EP | disclosed |
| US-5660645-A | MULTILAYER; SEMICONDUCTOR AND TRANSPARENT SURFACE | CANON KABUSHIKI KAISHA (JP) | 1997-08-26 | — | — | US | disclosed |
| EP-0680096-A2 | Solar cell module | CANON KABUSHIKI KAISHA (JP) | 1995-11-02 | — | — | EP | disclosed |