Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | PDE9A | O76083 | 1/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.36 |
| ▸ | CDK7 | P50613 | 1/20 | 0.36 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
| ▸ | CCNH | P51946 | 1/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7876154 | 0.73 | PDE9A (0.56) | CDK2SMN1; SMN2ALDH1A1HTTL3MBTL1 | |
| SCHEMBL3002806 | 0.68 | JAK2 (0.48) | CDK2SMN1; SMN2ALDH1A1HTTL3MBTL1 | |
| SCHEMBL7883156 | 0.67 | PDE9A (0.49) | CDK2SMN1; SMN2ALDH1A1HTTL3MBTL1 | |
| SCHEMBL16649501 | 0.66 | HTT (0.47) | CDK2SMN1; SMN2ALDH1A1HTTL3MBTL1 | |
| SCHEMBL6131742 | 0.61 | PDE9A (0.43) | CDK2ALDH1A1PDE9ACCNT1CDK1 | |
| SCHEMBL481407 | 0.60 | DYRK1A (0.53) | SMN1; SMN2ALDH1A1HTTRECQL | |
| SCHEMBL6642975 | 0.60 | ALDH1A1 (0.53) | SMN1; SMN2ALDH1A1HTTRECQL | |
| Oxypurinol SCHEMBL8256863 | 0.60 | ALDH1A1 (0.53) | SMN1; SMN2ALDH1A1HTTL3MBTL1RECQL | |
| SCHEMBL4497867 | 0.60 | ALDH1A1 (0.57) | SMN1; SMN2ALDH1A1HTTRECQL | |
| SCHEMBL13896216 | 0.60 | CDK2 (0.73) | CDK2CCNT1CDK1CCNB1CDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1534285-A2 | SELECTIVE PHOSPHODIESTERASE 9A INHIBITORS AS MEDICAMENTS FOR IMPROVING COGNITIVE PROCESSES | Bayer HealthCare AG (DE) | 2005-06-01 | — | — | EP | disclosed |
| WO-2004026286-A2 | SELECTIVE PHOSPHODIESTERASE 9A INHIBITORS AS MEDICAMENTS FOR IMPROVING COGNITIVE PROCESSES | BAYER HEALTHCARE AG (DE) | 2004-04-01 | — | — | WO | disclosed |