Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE9A | O76083 | 2/20 | 0.43 |
| ▸ | CDK2 | P24941 | 2/20 | 0.42 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.37 |
| ▸ | CDK7 | P50613 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | CCNH | P51946 | 1/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 2/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7876154 | 0.69 | PDE9A (0.56) | PDE9ACDK2ALDH1A1PDE1C | |
| SCHEMBL17615879 | 0.68 | TRPC5 (0.44) | CDK2CCNT1CDK1CCNB1CDK7 | |
| SCHEMBL17870123 | 0.66 | GAA (0.40) | PIK3CAMTORGAAALOX15ALDH1A1 | |
| SCHEMBL7883156 | 0.63 | PDE9A (0.49) | PDE9ACDK2ALDH1A1PDE1C | |
| SCHEMBL14722217 | 0.61 | TRPC5 (0.42) | PDE9ACDK2JAK2PDE1CJAK1 | |
| SCHEMBL6131743 | 0.61 | CDK2 (0.43) | PDE9ACDK2CCNT1CDK1CCNB1 | |
| SCHEMBL23310487 | 0.61 | ALDH1A1 (0.47) | GAAALOX15ALDH1A1JAK2GSK3B | |
| SCHEMBL7480350 | 0.61 | GAA (0.37) | PIK3CAMTORGAAALOX15ALDH1A1 | |
| SCHEMBL12895942 | 0.60 | ALOX15 (0.47) | GAAALOX15ALDH1A1JAK2GSK3B | |
| SCHEMBL1664897 | 0.60 | PDE9A (1.00) | PDE9APDE1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1534285-A2 | SELECTIVE PHOSPHODIESTERASE 9A INHIBITORS AS MEDICAMENTS FOR IMPROVING COGNITIVE PROCESSES | Bayer HealthCare AG (DE) | 2005-06-01 | — | — | EP | disclosed |
| WO-2004026286-A2 | SELECTIVE PHOSPHODIESTERASE 9A INHIBITORS AS MEDICAMENTS FOR IMPROVING COGNITIVE PROCESSES | BAYER HEALTHCARE AG (DE) | 2004-04-01 | — | — | WO | disclosed |