SCHEMBL6131970

SCHEMBL6131970

COC(=O)c1c2c(c3cc(OC)c(OC)cc3c1-c1ccc(OC)c(OC)c1)OC(c1ccc(OC)cc1)(c1ccc(OC)cc1)C=C2

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 5/20 0.45
SLC10A2 Q12908 1/20 0.40
ABCC1 P33527 2/20 0.39
ABCG2 Q9UNQ0 2/20 0.39
TDP1 Q9NUW8 3/20 0.38
KMT2A Q03164 1/20 0.38
NPC1 O15118 1/20 0.38
EDNRB P24530 1/20 0.37
EDNRA P25101 1/20 0.37
MAPT P10636 3/20 0.37
MAPK1 P28482 2/20 0.37
ALDH1A1 P00352 2/20 0.37
HPGD P15428 2/20 0.37
HSD17B10 Q99714 1/20 0.37
PDE1A P54750 1/20 0.37
PDE1B Q01064 1/20 0.37
PDE3B Q13370 1/20 0.37
PDE1C Q14123 1/20 0.37
PDE3A Q14432 1/20 0.37
LMNA P02545 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6131971 0.93 L3MBTL1 (0.41) L3MBTL1SLC10A2ABCC1ABCG2TDP1
SCHEMBL6131952 0.91 SLC10A2 (0.41) L3MBTL1SLC10A2KMT2AMAPTMAPK1
SCHEMBL6131950 0.90 L3MBTL1 (0.41) L3MBTL1TDP1KMT2AEDNRBEDNRA
SCHEMBL6131983 0.86 L3MBTL1 (0.42) L3MBTL1TDP1KMT2ANPC1MAPT
SCHEMBL6132018 0.86 L3MBTL1 (0.41) L3MBTL1TDP1KMT2AMAPTMAPK1
SCHEMBL5107921 0.82 L3MBTL1 (0.40) L3MBTL1TDP1KMT2AMAPTALDH1A1
SCHEMBL6169985 0.81 L3MBTL1 (0.43) L3MBTL1TDP1NPC1EDNRAMAPT
SCHEMBL6131933 0.80 KMT2A (0.34) L3MBTL1KMT2ANPC1MAPTALDH1A1
SCHEMBL8920456 0.79 L3MBTL1 (0.39) L3MBTL1TDP1KMT2ANPC1MAPT
SCHEMBL29565468 0.79 L3MBTL1 (0.39) L3MBTL1TDP1KMT2ANPC1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1214310-B1 NOVEL PHOTOCHROMIC NAPHTHOPYRANS TRANSITIONS OPTICAL INC (US) 2005-04-27 EP claimed
US-6348604-B1 COMPOUNDS IN WHICH SELECTION AND PLACEMENT OF SUBSTITUENTS CONTROL WAVELENGTH AND/OR INTENSITY OF VISIBLE ABSORBANCE BANDS PPG INDUSTRIES OHIO, INC. 2002-02-19 US claimed
US-10758643-B2 Mechanophoric medical product AESCULAP AG (DE) 2020-09-01 US disclosed
EP-3331581-B1 MECHANOPHORIC MEDICAL PRODUKT AESCULAP AG (DE) 2020-07-08 EP disclosed
US-20190151502-A1 Mechanophoric Medical Product AESCULAP AG (DE) 2019-05-23 US disclosed
EP-3331581-A1 MECHANOPHORIC MEDICAL PRODUCT Aesculap AG (DE) 2018-06-13 EP disclosed
WO-2017025408-A1 MECHANOPHORIC MEDICAL PRODUCT AESCULAP AG (DE) 2017-02-16 WO disclosed
EP-1214310-B1 NOVEL PHOTOCHROMIC NAPHTHOPYRANS TRANSITIONS OPTICAL INC (US) 2005-04-27 EP disclosed
US-6348604-B1 COMPOUNDS IN WHICH SELECTION AND PLACEMENT OF SUBSTITUENTS CONTROL WAVELENGTH AND/OR INTENSITY OF VISIBLE ABSORBANCE BANDS PPG INDUSTRIES OHIO, INC. 2002-02-19 US disclosed