Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.66 |
| ▸ | ABCB1 | P08183 | 13/20 | 0.63 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
| ▸ | ABCC1 | P33527 | 4/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.58 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6131953 | 0.87 | KDM4E (0.66) | KDM4ETDP1ABCB1MAPTGAA | |
| SCHEMBL3059412 | 0.80 | KDM4E (0.86) | KDM4ETDP1ABCB1MAPTGAA | |
| SCHEMBL6132050 | 0.80 | ABCB1 (0.82) | KDM4ETDP1ABCB1MAPTGAA | |
| SCHEMBL6131920 | 0.80 | KMT2A (0.57) | KDM4EKMT2AALDH1A1 | |
| SCHEMBL6131918 | 0.78 | KMT2A (0.55) | KDM4EKMT2AALDH1A1 | |
| SCHEMBL6131995 | 0.77 | MAPT (0.61) | KDM4EMAPTKMT2AALDH1A1NPSR1 | |
| SCHEMBL9416542 | 0.76 | KDM4E (0.79) | KDM4ETDP1ABCB1MAPTGAA | |
| SCHEMBL29836069 | 0.76 | KDM4E (0.93) | KDM4ETDP1ABCB1MAPTGAA | |
| Hydrochloric Acid SCHEMBL6131860 | 0.76 | SMN1; SMN2 (0.60) | KDM4EMAPTKMT2AALDH1A1NPSR1 | |
| SCHEMBL6131943 | 0.76 | KDM4E (0.63) | KDM4ETDP1KMT2AALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1032559-A4 | AMINOALKYLPHENOL DERIVATIVES AND RELATED COMPOUNDS | AVENTIS PHARMA INC (US) | 2005-05-25 | — | — | EP | disclosed |
| US-6479495-B1 | SIMULTANEOUSLY TREATING DEPRESSION AND MEMORY DYSFUNCTION IN MAMMALS SUFFERING FROM MEMORY DYSFUNCTION AND DEPRESSION | AVENTIS PHARMACEUTICALS INC. | 2002-11-12 | — | — | US | disclosed |
| EP-1032559-A1 | AMINOALKYLPHENOL DERIVATIVES AND RELATED COMPOUNDS | AVENTIS PHARMACEUTICALS INC. (US) | 2000-09-06 | — | — | EP | disclosed |
| WO-1999016746-A1 | AMINOALKYLPHENOL DERIVATIVES AND RELATED COMPOUNDS | AVENTIS PHARMACEUTICALS INC. (US) | 1999-04-08 | — | — | WO | disclosed |