Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | THRA | P10827 | 2/20 | 0.35 |
| ▸ | THRB | P10828 | 2/20 | 0.35 |
| ▸ | ATF4 | P18848 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NAAA | Q02083 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15159536 | 0.83 | THRA (0.42) | EPHX1ALDH1A1THRATHRBNPC1 | |
| SCHEMBL1734827 | 0.83 | THRA (0.42) | EPHX1ALDH1A1THRATHRBNPC1 | |
| SCHEMBL9132526 | 0.83 | THRA (0.42) | EPHX1ALDH1A1THRATHRBNPC1 | |
| SCHEMBL27451178 | 0.83 | THRA (0.42) | EPHX1ALDH1A1THRATHRBNPC1 | |
| SCHEMBL16204628 | 0.83 | THRA (0.42) | EPHX1ALDH1A1THRATHRBNPC1 | |
| SCHEMBL24564741 | 0.83 | THRA (0.42) | EPHX1ALDH1A1THRATHRBNPC1 | |
| SCHEMBL27437029 | 0.82 | EPHX1 (0.42) | EPHX1NPSR1ATF4NPC1NAAA | |
| SCHEMBL5672230 | 0.81 | EPHX2 (0.42) | EPHX1NPSR1ATF4NAAACYP2C19 | |
| SCHEMBL360541 | 0.81 | ITGB3 (0.41) | EPHX1THRATHRBATF4NPC1 | |
| SCHEMBL7900018 | 0.78 | EPHX2 (0.40) | EPHX1NPSR1ATF4NAAACYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050075342-A1 | Pyrrolopyridazine derivatives | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2005-04-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050075342-A1 | Pyrrolopyridazine derivatives | PDE4A, PDE5A, PDE12 | EPHX1 997/4885ALDH1A1 328/4885NPSR1 1002/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.