Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.45 |
| ▸ | XIAP | P98170 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6133630 | 0.91 | ALDH1A1 (0.46) | ALDH1A1MAPTHTTADORA2AADORA1 | |
| SCHEMBL6133303 | 0.88 | ADORA2A (0.60) | ALDH1A1MAPTHTTADORA2AADORA1 | |
| SCHEMBL6133349 | 0.87 | ADORA2A (0.53) | ALDH1A1MAPTHTTADORA2AADORA1 | |
| SCHEMBL6133409 | 0.87 | ADORA2A (0.57) | ALDH1A1MAPTHTTADORA2AADORA1 | |
| SCHEMBL6133367 | 0.86 | ADORA1 (0.50) | ALDH1A1MAPTHTTADORA2AADORA1 | |
| SCHEMBL6133654 | 0.85 | ALDH1A1 (0.54) | ALDH1A1MAPTHTTADORA2AADORA1 | |
| SCHEMBL6135469 | 0.84 | XIAP (0.55) | ALDH1A1MAPTHTTADORA2AADORA1 | |
| SCHEMBL6133156 | 0.84 | CNR1 (0.47) | ALDH1A1MAPTHTTADORA2AADORA1 | |
| SCHEMBL6134312 | 0.84 | ALDH1A1 (0.47) | ALDH1A1MAPTHTTADORA2AADORA1 | |
| SCHEMBL6133625 | 0.84 | ADORA2A (0.56) | ALDH1A1MAPTHTTADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050004134-A1 | Thiazole derivative and pharmaceutical use thereof | ASTELLAS PHARMA INC. (JP) | 2005-01-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050004134-A1 | Thiazole derivative and pharmaceutical use thereof | MC2R, CYP2C9, OXTR | ALDH1A1 630/4885MAPT 3008/4885HTT 477/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.