Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.38 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.38 |
| ▸ | L3MBTL4 | Q8NA19 | 1/20 | 0.38 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6134440 | 0.91 | KMT2A (0.45) | SMN1; SMN2RAB9AKMT2AMEN1ALDH1A1 | |
| SCHEMBL6135046 | 0.86 | KMT2A (0.46) | KMT2AMEN1ALDH1A1KDM4EMAPT | |
| SCHEMBL6135117 | 0.85 | HRH3 (0.42) | SMN1; SMN2RAB9ANPC1KMT2AMEN1 | |
| SCHEMBL6134698 | 0.84 | ALDH1A1 (0.47) | SMN1; SMN2KMT2AMEN1ALDH1A1TDP1 | |
| SCHEMBL6134612 | 0.82 | ALDH1A1 (0.49) | SMN1; SMN2RAB9ANPC1KMT2AMEN1 | |
| SCHEMBL6134989 | 0.82 | ALDH1A1 (0.51) | KMT2AMEN1ALDH1A1KDM4ETDP1 | |
| SCHEMBL6132317 | 0.81 | ALDH1A1 (0.50) | SMN1; SMN2RAB9ANPC1KMT2AMEN1 | |
| SCHEMBL6134631 | 0.81 | HDAC3 (0.50) | SMN1; SMN2KMT2AMEN1ALDH1A1KDM4E | |
| SCHEMBL6134863 | 0.80 | KMT2A (0.51) | RAB9ANPC1KMT2AMEN1ALDH1A1 | |
| SCHEMBL6134378 | 0.78 | ALDH1A1 (0.51) | SMN1; SMN2KMT2AMEN1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050261177-A1 | Compound | ASTELLAS PHARMA INC. (JP) | 2005-11-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050261177-A1 | Compound | MANBA, MAN2B1, MAN2A1 | SMN1; SMN2 3682/4885RAB9A 3326/4885NPC1 1070/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.