Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.42 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.38 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.38 |
| ▸ | L3MBTL4 | Q8NA19 | 1/20 | 0.38 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6134210 | 0.89 | MEN1 (0.46) | KMT2AMEN1ITGB3ITGA2BALOX15 | |
| SCHEMBL6135040 | 0.86 | SMN1; SMN2 (0.43) | KMT2AMEN1HDAC3HDAC8MBTD1 | |
| SCHEMBL6134698 | 0.83 | ALDH1A1 (0.47) | KMT2AMEN1ITGB3ITGA2BMAPT | |
| SCHEMBL6135305 | 0.79 | HRH3 (0.51) | KMT2AMEN1ITGB3ITGA2BALOX15 | |
| SCHEMBL6134717 | 0.79 | ITGB3 (0.52) | KMT2AMEN1ITGB3ITGA2BALOX15 | |
| SCHEMBL6132283 | 0.78 | MEN1 (0.55) | KMT2AMEN1ITGB3ITGA2BALOX15 | |
| SCHEMBL6134192 | 0.78 | ITGB3 (0.51) | KMT2AMEN1ITGB3ITGA2BALOX15 | |
| SCHEMBL6134481 | 0.77 | HRH3 (0.44) | KMT2AMEN1ITGB3ITGA2BHRH3 | |
| SCHEMBL6135117 | 0.77 | HRH3 (0.42) | KMT2AMEN1HRH3MAPTALDH1A1 | |
| SCHEMBL6134440 | 0.76 | KMT2A (0.45) | KMT2AMEN1ALOX15HDAC3HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050261177-A1 | Compound | ASTELLAS PHARMA INC. (JP) | 2005-11-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050261177-A1 | Compound | MANBA, MAN2B1, MAN2A1 | KMT2A 4492/4885MEN1 880/4885ITGB3 1732/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.