Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 10/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.40 |
| ▸ | C1R | P00736 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2078192 | 1.00 | ELANE (0.47) | ELANEMAPTKDM4EALDH1A1MEN1 | |
| SCHEMBL2076616 | 1.00 | ELANE (0.47) | ELANEMAPTKDM4EALDH1A1MEN1 | |
| SCHEMBL6135176 | 1.00 | ELANE (0.47) | ELANEMAPTKDM4EALDH1A1MEN1 | |
| SCHEMBL2076618 | 1.00 | ELANE (0.47) | ELANEMAPTKDM4EALDH1A1MEN1 | |
| SCHEMBL2078194 | 1.00 | ELANE (0.47) | ELANEMAPTKDM4EALDH1A1MEN1 | |
| SCHEMBL2078347 | 0.93 | ELANE (0.54) | ELANEMAPTKDM4EALDH1A1MEN1 | |
| SCHEMBL2076594 | 0.93 | ELANE (0.54) | ELANEMAPTKDM4EALDH1A1MEN1 | |
| SCHEMBL2078034 | 0.93 | ELANE (0.54) | ELANEMAPTKDM4EALDH1A1MEN1 | |
| SCHEMBL2076590 | 0.93 | ELANE (0.54) | ELANEMAPTKDM4EALDH1A1MEN1 | |
| SCHEMBL2078098 | 0.93 | ELANE (0.54) | ELANEMAPTKDM4EALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1143977-B3 | 2-OXY-BENZOXAZINONE DERIVATIVES FOR THE TREATMENT OF OBESITY | NORGINE BV (NL) | 2012-10-24 | — | — | EP | claimed |
| EP-1143977-B1 | 2-OXY-BENZOXAZINONE DERIVATIVES FOR THE TREATMENT OF OBESITY | ALIZYME THERAPEUTICS LTD (GB) | 2005-04-20 | — | — | EP | claimed |
| US-20030195206-A1 | An enzyme inhibitors, enzyme is to catalyse the hydrolysis of an ester; treating hyperlipaemia, hyperglycaemia (type II diabetes), hypertension, cardiovascular disorders stroke, gastrointestinal disease; chemical intermediate synthesis | NORGINE B.V. (NL) | 2003-10-16 | — | — | US | claimed |
| US-6624161-B2 | Administering 2-oxy substituted benzoxazin-5-one derivative to a human or animal for the prevention or treatment of obesity or an obesity related disorder | ALIZYME THERAPEUTICS LIMITED (GB) | 2003-09-23 | — | — | US | claimed |
| US-20030027821-A1 | Administering 2-oxy substituted benzoxazin-5-one derivative to a human or animal for the prevention or treatment of obesity or an obesity related disorder | NORGINE B.V. (NL) | 2003-02-06 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030027821-A1 | Administering 2-oxy substituted benzoxazin-5-one derivative to a human or animal for the prevention or treatment of obesity or an obesity related disorder | CYP2F1, BBOX1, CES1 | ELANE 1134/4885MAPT 4061/4885KDM4E 1177/4885 |
| US-20030195206-A1 | An enzyme inhibitors, enzyme is to catalyse the hydrolysis of an ester; treating hyperlipaemia, hyperglycaemia (type II diabetes), hypertension, cardiovascular disorders stroke, gastrointestinal disease; chemical intermediate synthesis | CES1, LIPC, PNLIP | ELANE 1412/4885MAPT 2799/4885KDM4E 1682/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.