Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | S100A9 | P06702 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24767550 | 0.82 | ALDH1A1 (0.49) | MAPTMEN1KMT2AALDH1A1MAPK1 | |
| SCHEMBL14992081 | 0.81 | TAAR1 (0.41) | MAPTMEN1KMT2AALDH1A1MAPK1 | |
| SCHEMBL1502524 | 0.80 | POLB (0.39) | MAPTMEN1KMT2AALDH1A1MAPK1 | |
| SCHEMBL14025883 | 0.79 | MAPT (0.38) | MAPTMEN1KMT2AALDH1A1MAPK1 | |
| SCHEMBL17827970 | 0.78 | GCK (0.39) | HCAR2S100A9ABCB11 | |
| SCHEMBL16213410 | 0.78 | LMNA (0.35) | MAPTMEN1KMT2AALDH1A1MAPK1 | |
| SCHEMBL14211406 | 0.78 | POLB (0.36) | MAPTMEN1KMT2AALDH1A1MAPK1 | |
| SCHEMBL783480 | 0.78 | CYP11B2 (0.41) | MAPTMEN1KMT2AALDH1A1MAPK1 | |
| SCHEMBL3465480 | 0.78 | POLB (0.36) | MAPTMEN1KMT2AALDH1A1MAPK1 | |
| SCHEMBL3472642 | 0.78 | CYP11B2 (0.41) | MAPTMEN1KMT2AALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1592419-A1 | USE OF PHOSPHODIESTERASE-4 INHIBITORS AS ENHANCERS OF COGNITION | Merck Frosst Canada & Co. (CA) | 2005-11-09 | — | — | EP | disclosed |
| WO-2004047836-A1 | USE OF PHOSPHODIESTERASE-4 INHIBITORS AS ENHANCERS OF COGNITION | MERCK FROSST CANADA & CO. (CA) | 2004-06-10 | — | — | WO | disclosed |