Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 9/20 | 0.61 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.54 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SHMT1 | P34896 | 1/20 | 0.49 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.49 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | CNR1 | P21554 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6136330 | 1.00 | CNR2 (0.61) | CNR2PSMB8PSMB5KMT2AALDH1A1 | |
| SCHEMBL6136486 | 0.85 | HPGD (0.58) | CNR2PSMB8PSMB5KMT2AALDH1A1 | |
| SCHEMBL6136490 | 0.85 | HPGD (0.58) | CNR2PSMB8PSMB5KMT2AALDH1A1 | |
| SCHEMBL2177216 | 0.84 | POLB (0.63) | CNR2PSMB8PSMB5KMT2AALDH1A1 | |
| SCHEMBL2177223 | 0.84 | POLB (0.63) | CNR2PSMB8PSMB5KMT2AALDH1A1 | |
| SCHEMBL18885276 | 0.84 | CNR2 (0.67) | CNR2PSMB8PSMB5KMT2AALDH1A1 | |
| SCHEMBL8035990 | 0.84 | POLB (0.63) | CNR2PSMB8PSMB5KMT2AALDH1A1 | |
| SCHEMBL6136711 | 0.83 | THRA (0.46) | CNR2ALDH1A1SHMT1SHMT2POLB | |
| SCHEMBL6136706 | 0.83 | THRA (0.46) | CNR2ALDH1A1SHMT1SHMT2POLB | |
| SCHEMBL6136504 | 0.83 | L3MBTL1 (0.49) | KMT2AALDH1A1LMNAL3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0951464-B1 | N-(ARYL/HETEROARYLACETYL) AMINO ACID ESTERS, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, AND METHODS FOR INHIBITING BETA-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS BY USE OF SUCH COMPOUNDS | ELAN PHARM INC (US) | 2005-05-11 | — | — | EP | claimed |