Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 2/20 | 0.46 |
| ▸ | THRB | P10828 | 2/20 | 0.46 |
| ▸ | SHMT1 | P34896 | 1/20 | 0.46 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.46 |
| ▸ | GRN | P28799 | 3/20 | 0.44 |
| ▸ | SORT1 | Q99523 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 4/20 | 0.42 |
| ▸ | ACLY | P53396 | 1/20 | 0.41 |
| ▸ | CCKBR | P32239 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
| ▸ | TACR1 | P25103 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6136711 | 1.00 | THRA (0.46) | THRATHRBSHMT1SHMT2GRN | |
| SCHEMBL4414835 | 0.84 | ALDH1A1 (0.52) | SHMT1SHMT2ALDH1A1SMN1; SMN2KDM4C | |
| SCHEMBL4414837 | 0.84 | ALDH1A1 (0.52) | SHMT1SHMT2ALDH1A1SMN1; SMN2KDM4C | |
| SCHEMBL6136330 | 0.83 | CNR2 (0.61) | SHMT1SHMT2ALDH1A1CNR2POLB | |
| SCHEMBL6136328 | 0.83 | CNR2 (0.61) | SHMT1SHMT2ALDH1A1CNR2POLB | |
| SCHEMBL4417385 | 0.80 | ALDH1A1 (0.40) | THRATHRBGRNSORT1ALDH1A1 | |
| SCHEMBL6136789 | 0.80 | ALDH1A1 (0.40) | THRATHRBGRNSORT1ALDH1A1 | |
| SCHEMBL3088596 | 0.80 | SMYD3 (0.48) | THRATHRBKDM4EALDH1A1 | |
| SCHEMBL4106052 | 0.80 | SMYD3 (0.48) | THRATHRBKDM4EALDH1A1 | |
| SCHEMBL14367229 | 0.80 | SMYD3 (0.48) | THRATHRBKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0951464-B1 | N-(ARYL/HETEROARYLACETYL) AMINO ACID ESTERS, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, AND METHODS FOR INHIBITING BETA-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS BY USE OF SUCH COMPOUNDS | ELAN PHARM INC (US) | 2005-05-11 | — | — | EP | claimed |