Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 3/20 | 0.39 |
| ▸ | MME | P08473 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ACACB | O00763 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ACE | P12821 | 1/20 | 0.38 |
| ▸ | CPA1 | P15085 | 1/20 | 0.38 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4424684 | 1.00 | SMN1; SMN2 (0.49) | SMN1; SMN2LTA4HPOLBALDH1A1MAPT | |
| SCHEMBL6136574 | 0.92 | LTA4H (0.52) | SMN1; SMN2LTA4HPOLBALDH1A1MAPT | |
| SCHEMBL4414768 | 0.92 | LTA4H (0.52) | SMN1; SMN2LTA4HPOLBALDH1A1MAPT | |
| SCHEMBL6136289 | 0.91 | LTA4H (0.55) | SMN1; SMN2LTA4HPOLBRAB9AEPHX1 | |
| SCHEMBL6136293 | 0.91 | LTA4H (0.55) | SMN1; SMN2LTA4HPOLBRAB9AEPHX1 | |
| SCHEMBL10199651 | 0.81 | KMT2A (0.45) | FAAHACACBRAB9ATSHREPHX1 | |
| SCHEMBL4412011 | 0.81 | TSHR (0.45) | POLBALDH1A1MAPTACACBTSHR | |
| SCHEMBL6136272 | 0.81 | TSHR (0.45) | POLBALDH1A1MAPTACACBTSHR | |
| SCHEMBL25480858 | 0.78 | ACACB (0.39) | LTA4HACACBRAB9AEPHX1 | |
| SCHEMBL23187995 | 0.78 | ACACB (0.39) | LTA4HACACBRAB9AEPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0951464-B1 | N-(ARYL/HETEROARYLACETYL) AMINO ACID ESTERS, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, AND METHODS FOR INHIBITING BETA-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS BY USE OF SUCH COMPOUNDS | ELAN PHARM INC (US) | 2005-05-11 | — | — | EP | claimed |