Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MME | P08473 | 1/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4414768 | 1.00 | LTA4H (0.52) | LTA4HKMT2AHPGDEPHX1SMN1; SMN2 | |
| SCHEMBL6136293 | 0.98 | LTA4H (0.55) | LTA4HKMT2AHPGDEPHX1SMN1; SMN2 | |
| SCHEMBL6136289 | 0.98 | LTA4H (0.55) | LTA4HKMT2AHPGDEPHX1SMN1; SMN2 | |
| SCHEMBL6136421 | 0.92 | SMN1; SMN2 (0.49) | LTA4HEPHX1SMN1; SMN2RAB9APOLB | |
| SCHEMBL4424684 | 0.92 | SMN1; SMN2 (0.49) | LTA4HEPHX1SMN1; SMN2RAB9APOLB | |
| SCHEMBL7882899 | 0.84 | KMT2A (0.53) | KMT2AHPGDEPHX1SMN1; SMN2EPHX2 | |
| SCHEMBL7437533 | 0.82 | HPGD (0.57) | LTA4HKMT2AHPGDEPHX1SMN1; SMN2 | |
| SCHEMBL6136201 | 0.82 | KMT2A (0.44) | KMT2AHPGDEPHX1EPHX2PSEN1 | |
| SCHEMBL15906239 | 0.82 | ALDH1A1 (0.54) | LTA4HKMT2AHPGDEPHX1SMN1; SMN2 | |
| SCHEMBL7411199 | 0.82 | LTA4H (0.50) | LTA4HKMT2AHPGDEPHX1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0951464-B1 | N-(ARYL/HETEROARYLACETYL) AMINO ACID ESTERS, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, AND METHODS FOR INHIBITING BETA-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS BY USE OF SUCH COMPOUNDS | ELAN PHARM INC (US) | 2005-05-11 | — | — | EP | claimed |