Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 2/20 | 0.76 |
| ▸ | HTR1D | P28221 | 1/20 | 0.76 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.65 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | NSD2 | O96028 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL595753 | 0.87 | HTR1B (1.00) | HTR1BHTR1DMTNR1AMTNR1BL3MBTL1 | |
| Iodide SCHEMBL30481083 | 0.85 | HTR1B (0.96) | HTR1BHTR1DMTNR1AMTNR1BL3MBTL1 | |
| Hydrochloric Acid SCHEMBL10921722 | 0.85 | HTR1B (0.96) | HTR1BHTR1DMTNR1AMTNR1BL3MBTL1 | |
| SCHEMBL1109801 | 0.81 | HTR1B (1.00) | HTR1BHTR1DMTNR1AMTNR1BL3MBTL1 | |
| SCHEMBL13715503 | 0.79 | PARP10 (0.62) | HTR1BHTR1DL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL1053081 | 0.79 | MTNR1A (0.69) | HTR1BHTR1DMTNR1AMTNR1BL3MBTL1 | |
| Acetamide SCHEMBL27512267 | 0.79 | LTA4H (0.67) | L3MBTL1PARP10 | |
| SCHEMBL885015 | 0.79 | MTNR1A (1.00) | HTR1BHTR1DMTNR1AMTNR1BL3MBTL1 | |
| SCHEMBL8901248 | 0.78 | KDM4E (0.62) | HTR1BHTR1DMTNR1AMTNR1BL3MBTL1 | |
| SCHEMBL30344364 | 0.78 | PARP1 (0.57) | HTR1BHTR1DKDM4EALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0994105-B1 | 2-amino-pyridine intermediates for beta3-Adrenergic receptor agonists | PFIZER PROD INC (US) | 2005-12-14 | — | — | EP | disclosed |
| US-6124457-A | Process and intermediates for a β3 -adrenergic receptor agonist | PFIZER INC. (US) | 2000-09-26 | — | — | US | disclosed |
| US-6090942-A | Process and intermediates for a β3 -adrenergic receptor agonist | PFIZER INC. (US) | 2000-07-18 | — | — | US | disclosed |
| EP-0994105-A2 | 2-amino-pyridine intermediates for beta3-Adrenergic receptor agonists | Pfizer Products Inc. (US) | 2000-04-19 | — | — | EP | disclosed |