Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | NSD2 | O96028 | 1/20 | 0.60 |
| ▸ | HTR1B | P28222 | 2/20 | 0.53 |
| ▸ | HTR1D | P28221 | 1/20 | 0.53 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.51 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25822288 | 0.88 | KDM4E (0.62) | KDM4EALDH1A1SMN1; SMN2NSD2HTR1B | |
| SCHEMBL25820387 | 0.87 | KDM4E (0.60) | KDM4EALDH1A1SMN1; SMN2NSD2HTR1B | |
| SCHEMBL25822303 | 0.86 | KDM4E (0.49) | KDM4EALDH1A1SMN1; SMN2NSD2MTNR1A | |
| SCHEMBL4572134 | 0.85 | KDM4E (0.48) | KDM4EALDH1A1SMN1; SMN2NSD2MTNR1A | |
| SCHEMBL25820408 | 0.84 | KDM4E (0.58) | KDM4EALDH1A1SMN1; SMN2NSD2HTR1B | |
| SCHEMBL3968441 | 0.84 | MTNR1A (0.54) | KDM4EALDH1A1SMN1; SMN2NSD2MTNR1A | |
| SCHEMBL4569111 | 0.83 | KDM4E (0.47) | KDM4EALDH1A1SMN1; SMN2NSD2MTNR1A | |
| SCHEMBL4568923 | 0.83 | KMT2A (0.59) | ALDH1A1SMN1; SMN2KMT2AMAPK1L3MBTL1 | |
| SCHEMBL13881805 | 0.82 | MTNR1A (0.49) | KDM4EALDH1A1SMN1; SMN2NSD2MTNR1A | |
| SCHEMBL30344364 | 0.82 | PARP1 (0.57) | KDM4EALDH1A1SMN1; SMN2NSD2HTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120129894-A1 | Alkoxy Compounds for Disease Treatment | ACUCELA INC. (US) | 2012-05-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120129894-A1 | Alkoxy Compounds for Disease Treatment | ALDH1A2, CLN6, AGER | KDM4E 2349/4885ALDH1A1 140/4885SMN1; SMN2 42/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.