Known targets — ChEMBL curated mechanism
SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9A
The experimentally established mechanism targets of Ethotoin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.67 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | ELANE | P08246 | 3/20 | 0.38 |
| ▸ | EP300 | Q09472 | 1/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethotoin SCHEMBL34301 | 0.82 | LMNA (1.00) | LMNAADORA3ALDH1A1TSHREP300 | |
| Ethotoin SCHEMBL34302 | 0.82 | LMNA (1.00) | LMNAADORA3ALDH1A1TSHREP300 | |
| Metharbital SCHEMBL28086124 | 0.74 | LMNA (0.55) | LMNAALDH1A1TSHRELANECYP2C19 | |
| Metharbital SCHEMBL78867 | 0.72 | ATM (0.60) | LMNAALDH1A1TSHRELANESMN1; SMN2 | |
| Phenytoin SCHEMBL4657062 | 0.72 | LMNA (0.68) | LMNAADORA3ALDH1A1TSHREP300 | |
| SCHEMBL11459127 | 0.71 | LMNA (0.71) | LMNAADORA3ALDH1A1TSHREP300 | |
| SCHEMBL5148364 | 0.70 | LMNA (0.66) | LMNAADORA3ALDH1A1TSHREP300 | |
| Mephobarbital SCHEMBL1004749 | 0.70 | LMNA (0.86) | LMNATSHRELANECYP2C19TDP1 | |
| SCHEMBL11017764 | 0.69 | LMNA (0.73) | LMNAADORA3ALDH1A1CYP2C19TDP1 | |
| SCHEMBL22265963 | 0.69 | LMNA (0.68) | LMNAADORA3ALDH1A1TSHRCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1337218-A4 | SUBSTITUTED FELBAMATE DERIVED COMPOUNDS | UNIV VIRGINIA (US) | 2005-08-10 | — | — | EP | disclosed |
| EP-1337218-A2 | SUBSTITUTED FELBAMATE DERIVED COMPOUNDS | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2003-08-27 | — | — | EP | disclosed |
| EP-1282414-A2 | FELBAMATE DERIVED COMPOUNDS | University of Virginia Patent Foundation (US) | 2003-02-12 | — | — | EP | disclosed |
| WO-2002056827-A2 | SUBSTITUTED FELBAMATE DERIVED COMPOUNDS | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2002-07-25 | — | — | WO | disclosed |
| EP-1156798-A4 | FELBAMATE DERIVED COMPOUNDS | UNIV VIRGINIA (US) | 2002-07-17 | — | — | EP | disclosed |
| EP-1156798-A1 | FELBAMATE DERIVED COMPOUNDS | THE UNIVERSITY OF VIRGINIA ALUMNI PATENTS FOUNDATION (US) | 2001-11-28 | — | — | EP | disclosed |
| WO-2001085149-A2 | FELBAMATE DERIVED COMPOUNDS | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2001-11-15 | — | — | WO | disclosed |
| WO-2000047202-A1 | FELBAMATE DERIVED COMPOUNDS | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2000-08-17 | — | — | WO | disclosed |