Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ
The experimentally established mechanism targets of Metharbital. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | ELANE | P08246 | 7/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Metharbital SCHEMBL28086124 | 0.83 | LMNA (0.55) | ATMLMNATSHRCYP2C19ELANE | |
| Metharbital SCHEMBL4885996 | 0.83 | LMNA (0.59) | ATMLMNASMN1; SMN2ELANEMEN1 | |
| Mephobarbital SCHEMBL1004749 | 0.79 | LMNA (0.86) | ATMLMNATSHRCYP2C19ELANE | |
| SCHEMBL11677956 | 0.78 | SMN1; SMN2 (0.46) | ATMLMNASMN1; SMN2TSHRCYP2C19 | |
| SCHEMBL31213553 | 0.76 | LMNA (0.48) | ATMLMNASMN1; SMN2CYP2C19ELANE | |
| SCHEMBL2049685 | 0.75 | GABRA1 (0.41) | ATMLMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL9334263 | 0.74 | LMNA (0.46) | ATMLMNASMN1; SMN2TSHRCYP2C19 | |
| SCHEMBL11730000 | 0.73 | ATM (0.50) | ATMLMNATSHRELANEALDH1A1 | |
| SCHEMBL31509083 | 0.72 | LMNA (0.78) | ATMLMNASMN1; SMN2TSHRCYP2C19 | |
| SCHEMBL11677957 | 0.70 | LMNA (0.47) | ATMLMNASMN1; SMN2ELANEALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 5204 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3441087-B1 | METHODS OF TREATING CHRONIC PAIN | TEVA PHARMACEUTICALS INT GMBH (CH) | 2025-02-19 | — | — | EP | claimed |
| US-20230218623-A1 | SALTS OF NEUROCEUTICALS AND USES THEREOF | SYNEURX INTERNATIONAL (TAIWAN) CORP. (TW) | 2023-07-13 | — | — | US | claimed |
| EP-4146656-A1 | SALTS OF NEUROCEUTICALS AND USES THEREOF | Syneurx International (Taiwan) Corp. (TW) | 2023-03-15 | — | — | EP | claimed |
| WO-2022164850-A1 | COMPOUNDS TO PREVENT OR TREAT SARS-CoV-2 VARIANT INFECTION | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) | 2022-08-04 | — | — | WO | claimed |
| EP-3618813-B1 | IMPROVED EXTENDED RELEASE HIGHLY LOADED DRUG COMPOSITIONS | LUBRIZOL ADVANCED MAT INC (US) | 2022-07-06 | — | — | EP | claimed |
| EP-1931320-B1 | MICROPARTICLES WITH MODIFIED RELEASE OF AT LEAST ONE ACTIVE PRINCIPLE AND ORAL DOSAGE FORM COMPRISING THE SAME | FLAMEL IRELAND LTD (IE) | 2022-06-15 | — | — | EP | claimed |
| US-20220016035-A1 | Extended Release Highly Loaded Drug Compositions | LUBRIZOL ADVANCED MATERIALS, INC. (US) | 2022-01-20 | — | — | US | claimed |
| WO-2021224830-A1 | SALTS OF NEUROCEUTICALS AND USES THEREOF | SYNEURX INTERNATIONAL (TAIWAN) CORP. (CN) | 2021-11-11 | — | — | WO | claimed |
| EP-3810184-A2 | METHODS OF TREATING OR INHIBITING ONSET OF HUNTINGTON'S DISEASE | University of Rochester (US) | 2021-04-28 | — | — | EP | claimed |
| WO-2021060998-A1 | PHARMACOLOGICAL COMPOSITION FOR TREATMENT OF NERVOUS TISSUE DYSFUNCTION, IN PARTICULAR VIRAL LATENCY, AND THE USE OF J05 ATC GROUP SUBSTANCES IN TREATMENT OF NERVOUS TISSUE DYSFUNCTION, IN PARTICULAR VIRAL LATENCY | CHUPTYŚ CONTISSI, Janusz (PL) | 2021-04-01 | — | — | WO | claimed |
| EP-0942752-A1 | ANTICONVULSANT CONTAINING COMPOSITION FOR TREATING NEUROPATHIC PAIN | Algos Pharmaceutical Corporation (US) | 1999-09-22 | — | — | EP | claimed |
| US-5811547-A | Method for inducing crystalline state transition in medicinal substance | NIPPON SHINYAJU CO., LTD. (JP) | 1998-09-22 | — | — | US | claimed |
| WO-1998007447-A1 | ANTICONVULSANT CONTAINING COMPOSITION FOR TREATING NEUROPATHIC PAIN | ALGOS PHARMACEUTICAL CORPORATION (US) | 1998-02-26 | — | — | WO | claimed |
| US-5700410-A | Method of manufacturing wax matrices | NIPPON SHINYAKU CO., LTD. (JP) | 1997-12-23 | — | — | US | claimed |
| EP-0580860-B1 | METHOD OF MANUFACTURING SOLID DISPERSION | NIPPON SHINYAKU CO LTD (JP) | 1997-10-22 | — | — | EP | claimed |
| US-4690824-A | Solid pharmaceutical formulations for slow, zero order release via controlled surface erosion: expanded range | REDI-ROWELL, INC. (US) | 1987-09-01 | — | — | US | claimed |
| EP-0154631-A4 | PROCESS FOR SELECTIVE NITRILE REDUCTION. | AMERICAN HOSPITAL SUPPLY CORP (US) | 1985-11-25 | — | — | EP | claimed |
| EP-0154631-A1 | PROCESS FOR SELECTIVE NITRILE REDUCTION | AMERICAN HOSPITAL SUPPLY CORPORATION (US) | 1985-09-18 | — | — | EP | claimed |
| WO-1985000605-A1 | PROCESS FOR SELECTIVE NITRILE REDUCTION | AMERICAN HOSPITAL SUPPLY CORPORATION (US) | 1985-02-14 | — | — | WO | claimed |
| US-4126684-A | 4-AMINO-3-P-HALOPHENYLBUTYRIC ACIDS AND THEIR DERIVATIVES USED IN THE CONTROL OF NARCOTIC ABUSE | CIBA-GEIGY CORPORATION (US) | 1978-11-21 | — | — | US | claimed |