Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.39 |
| ▸ | STAT3 | P40763 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5689580 | 1.00 | RAB9A (0.45) | RAB9ASMN1; SMN2GRIN2BKDM4EALDH1A1 | |
| SCHEMBL5689585 | 1.00 | RAB9A (0.45) | RAB9ASMN1; SMN2GRIN2BKDM4EALDH1A1 | |
| SCHEMBL5691476 | 0.87 | CYP1A2 (0.55) | RAB9ASMN1; SMN2GRIN2BKDM4EALDH1A1 | |
| SCHEMBL5691469 | 0.87 | CYP1A2 (0.55) | RAB9ASMN1; SMN2GRIN2BKDM4EALDH1A1 | |
| SCHEMBL4585219 | 0.82 | SMN1; SMN2 (0.39) | RAB9ASMN1; SMN2GRIN2BKDM4EALDH1A1 | |
| SCHEMBL4585228 | 0.82 | SMN1; SMN2 (0.39) | RAB9ASMN1; SMN2GRIN2BKDM4EALDH1A1 | |
| SCHEMBL4585225 | 0.82 | SMN1; SMN2 (0.39) | RAB9ASMN1; SMN2GRIN2BKDM4EALDH1A1 | |
| SCHEMBL6334993 | 0.80 | ALDH1A1 (0.39) | RAB9ASMN1; SMN2KDM4EALDH1A1KMT2A | |
| SCHEMBL6334992 | 0.80 | ALDH1A1 (0.39) | RAB9ASMN1; SMN2KDM4EALDH1A1KMT2A | |
| SCHEMBL8104515 | 0.80 | SMN1; SMN2 (0.40) | RAB9ASMN1; SMN2GRIN2BKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0994105-B1 | 2-amino-pyridine intermediates for beta3-Adrenergic receptor agonists | PFIZER PROD INC (US) | 2005-12-14 | — | — | EP | disclosed |
| US-6124457-A | Process and intermediates for a β3 -adrenergic receptor agonist | PFIZER INC. (US) | 2000-09-26 | — | — | US | disclosed |
| US-6090942-A | Process and intermediates for a β3 -adrenergic receptor agonist | PFIZER INC. (US) | 2000-07-18 | — | — | US | disclosed |
| EP-0994105-A2 | 2-amino-pyridine intermediates for beta3-Adrenergic receptor agonists | Pfizer Products Inc. (US) | 2000-04-19 | — | — | EP | disclosed |