Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 1/20 | 0.48 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.48 |
| ▸ | BRD4 | O60885 | 2/20 | 0.47 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.47 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.47 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | HK1 | P19367 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | GALK1 | P51570 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13772803 | 0.81 | NPC1 (0.53) | AHRPDK2BRD4CREBBPNPC1 | |
| SCHEMBL28321702 | 0.79 | AHR (0.52) | AHRPDK2BRD4CREBBPNPC1 | |
| SCHEMBL10679874 | 0.77 | LRRK2 (0.42) | AHRPDK2BRD4CREBBPMAPT | |
| Indene SCHEMBL28982398 | 0.74 | CA1 (0.43) | AHRPDK2BRD4CREBBPNPC1 | |
| SCHEMBL1268962 | 0.74 | HTR5A (0.42) | BRD4MAPTKMT2AHTR5ACYP1A2 | |
| SCHEMBL28850751 | 0.74 | PDE3B (0.35) | MAPTGAACYP1A2 | |
| SCHEMBL8874017 | 0.73 | GSK3B (0.56) | AHRPDK2BRD4CREBBPNPC1 | |
| SCHEMBL8874013 | 0.73 | GSK3B (0.56) | AHRPDK2BRD4CREBBPNPC1 | |
| SCHEMBL4994505 | 0.71 | PLAU (0.50) | AHRPDK2BRD4CREBBPNPC1 | |
| SCHEMBL23572479 | 0.68 | NPC1 (0.36) | AHRPDK2BRD4CREBBPNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015174812-A1 | IMPROVED METHOD FOR PREPARING ZILPATEROL | INTERQUIM, S.A. DE C.V. (MX) | 2015-11-19 | — | — | WO | claimed |
| EP-0659179-A4 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE. | MERCK & CO INC (US) | 1995-08-09 | — | — | EP | claimed |
| EP-0659179-A1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO. INC. (US) | 1995-06-28 | — | — | EP | claimed |
| EP-0272976-B1 | ZOOTECHNICAL COMPOSITIONS CONTAINING A BETA-ADRENERGIC BLOCKER | ROUSSEL-UCLAF (FR) | 1991-09-04 | — | — | EP | claimed |
| EP-0272976-A2 | Zootechnical compositions containing a beta-adrenergic blocker | ROUSSEL-UCLAF (FR) | 1988-06-29 | — | — | EP | claimed |
| EP-0107569-B1 | 6-AMINO-7-HYDROXY-4,5,6,7-TETRAHYDROIMIDAZO(4,5,1-J,K)(1)BENZAZEPIN-2(1H)-ONE DERIVATIVES, THEIR SALTS, THEIR PREPARATION, THEIR USE AS MEDICAMENTS AND COMPOSITIONS CONTAINING THEM | ROUSSEL-UCLAF (FR) | 1987-03-18 | — | — | EP | claimed |
| EP-0107569-A1 | 6-Amino-7-hydroxy-4,5,6,7-tetrahydroimidazo(4,5,1-j,k)(1)benzazepin-2(1H)-one derivatives, their salts, their preparation, their use as medicaments and compositions containing them | ROUSSEL-UCLAF (FR) | 1984-05-02 | — | — | EP | claimed |
| WO-2015174812-A1 | IMPROVED METHOD FOR PREPARING ZILPATEROL | INTERQUIM, S.A. DE C.V. (MX) | 2015-11-19 | — | — | WO | disclosed |
| WO-2014116684-A1 | NON-PEPTIDIC NEUROPEPTIDE Y RECEPTOR MODULATORS | ROBERTS EDWARD (US) | 2014-07-31 | — | — | WO | disclosed |
| US-7888345-B2 | Benzaepinones as sodium channel blockers | MERCK SHARP & DOHME CORP. (US) | 2011-02-15 | — | — | US | disclosed |
| US-20090181946-A1 | Benzaepinones as Sodium Channel Blockers | MERCK SHARP & DOHME CORP. | 2009-07-16 | — | — | US | disclosed |
| EP-1770087-A1 | Selected CGRP antagonists, process for their preparation as well as their use as medicaments | Boehringer Ingelheim Pharma GmbH & Co. KG (DE) | 2007-04-04 | — | — | EP | disclosed |
| EP-1229913-A4 | SUBSTITUTED 1-BENZAZEPINES AND DERIVATIVES THEREOF | ANTEXPHARMA INC (US) | 2005-01-19 | — | — | EP | disclosed |
| WO-1992016524-A1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1992-10-01 | — | — | WO | disclosed |
| EP-0272976-B1 | ZOOTECHNICAL COMPOSITIONS CONTAINING A BETA-ADRENERGIC BLOCKER | ROUSSEL-UCLAF (FR) | 1991-09-04 | — | — | EP | disclosed |
| EP-0272976-A2 | Zootechnical compositions containing a beta-adrenergic blocker | ROUSSEL-UCLAF (FR) | 1988-06-29 | — | — | EP | disclosed |
| EP-0107569-B1 | 6-AMINO-7-HYDROXY-4,5,6,7-TETRAHYDROIMIDAZO(4,5,1-J,K)(1)BENZAZEPIN-2(1H)-ONE DERIVATIVES, THEIR SALTS, THEIR PREPARATION, THEIR USE AS MEDICAMENTS AND COMPOSITIONS CONTAINING THEM | ROUSSEL-UCLAF (FR) | 1987-03-18 | — | — | EP | disclosed |
| EP-0107569-B1 | 6-AMINO-7-HYDROXY-4,5,6,7-TETRAHYDROIMIDAZO(4,5,1-J,K)(1)BENZAZEPIN-2(1H)-ONE DERIVATIVES, THEIR SALTS, THEIR PREPARATION, THEIR USE AS MEDICAMENTS AND COMPOSITIONS CONTAINING THEM | ROUSSEL-UCLAF (FR) | 1987-03-18 | — | — | EP | disclosed |
| EP-0107569-A1 | 6-Amino-7-hydroxy-4,5,6,7-tetrahydroimidazo(4,5,1-j,k)(1)benzazepin-2(1H)-one derivatives, their salts, their preparation, their use as medicaments and compositions containing them | ROUSSEL-UCLAF (FR) | 1984-05-02 | — | — | EP | disclosed |
| EP-0107569-A1 | 6-Amino-7-hydroxy-4,5,6,7-tetrahydroimidazo(4,5,1-j,k)(1)benzazepin-2(1H)-one derivatives, their salts, their preparation, their use as medicaments and compositions containing them | ROUSSEL-UCLAF (FR) | 1984-05-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090181946-A1 | Benzaepinones as Sodium Channel Blockers | TRPV1, TRPA1, KCNN1 | AHR 1654/4885PDK2 3711/4885BRD4 145/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.