Asparagine

Asparagine

SCHEMBL6136838

NC(=O)C[C@H](N)C(=O)O.O=C(O)CNC1CCCCCCCCCC1

nearest known ligand 0.43

Full drug profile on Sugi Atlas →

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
GRIK1 P39086 3/20 0.43
GRIK2 Q13002 1/20 0.41
ANPEP P15144 4/20 0.40
ERAP2 Q6P179 4/20 0.40
ALDH1A1 P00352 2/20 0.38
METAP1 P53582 1/20 0.37
KDM4E B2RXH2 3/20 0.36
MEN1 O00255 1/20 0.35
KMT2A Q03164 1/20 0.35
DPP7 Q9UHL4 5/20 0.35
DPP4 P27487 4/20 0.35
FAP Q12884 4/20 0.35
POLB P06746 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Asparagine SCHEMBL6136836 1.00 GRIK1 (0.43) GRIK1GRIK2ANPEPERAP2ALDH1A1
Leucine SCHEMBL6882071 0.84 SLC7A5 (0.53) GRIK1GRIK2ANPEPERAP2ALDH1A1
SCHEMBL18920966 0.83 METAP1 (0.44) GRIK1ANPEPERAP2ALDH1A1METAP1
Homoserine SCHEMBL9124592 0.82 METAP1 (0.40) GRIK1GRIK2ANPEPERAP2ALDH1A1
Leucine SCHEMBL7414158 0.82 SLC7A5 (0.55) GRIK1GRIK2ANPEPERAP2ALDH1A1
Alanine SCHEMBL5219005 0.81 ANPEP (0.44) ANPEPERAP2ALDH1A1METAP1KDM4E
SCHEMBL159315 0.80 ALDH1A1 (0.50) ALDH1A1KDM4EMEN1KMT2ADPP7
SCHEMBL250459 0.80 ALDH1A1 (0.50) ALDH1A1KDM4EMEN1KMT2ADPP7
SCHEMBL122347 0.80 ALDH1A1 (0.50) ALDH1A1KDM4EMEN1KMT2ADPP7
SCHEMBL173401 0.80 ALDH1A1 (0.50) ALDH1A1KDM4EMEN1KMT2ADPP7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1534333-A4 A METHOD OF IMMUNOMODULATION ORDER SISTERS OF MERCY QUEENSL (AU) 2005-10-19 EP disclosed
EP-1534333-A1 A METHOD OF IMMUNOMODULATION The Corporation Of The Trustees Of The Order Of The Sisters Of Mercy In Queensland (AU) 2005-06-01 EP disclosed
WO-2004014422-A1 A METHOD OF IMMUNOMODULATION THE CORPORATION OF THE TRUSTEES OF THE ORDER OF THE SISTERS OF MERCY IN QUEENSLAND (AU) 2004-02-19 WO disclosed
WO-2004007417-A1 ENZYME INHIBITORS THE AUSTRALIAN NATIONAL UNIVERSITY (AU) 2004-01-22 WO disclosed