Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 17/20 | 0.40 |
| ▸ | CASP7 | P55210 | 16/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | CASP9 | P55211 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6137021 | 0.93 | CASP3 (0.40) | CASP3CASP7CASP1CASP9OPRM1 | |
| SCHEMBL6137020 | 0.93 | CASP3 (0.40) | CASP3CASP7CASP1CASP9OPRM1 | |
| SCHEMBL27552241 | 0.90 | PLAU (0.39) | NAMPTOPRM1OPRK1 | |
| SCHEMBL27552112 | 0.86 | CASP3 (0.37) | CASP3 | |
| SCHEMBL27571760 | 0.80 | CXCR2 (0.45) | — | |
| SCHEMBL6139839 | 0.79 | VEGFA (0.32) | CASP3CASP7 | |
| SCHEMBL6564039 | 0.78 | CXCR2 (0.55) | — | |
| SCHEMBL6563959 | 0.77 | CASP3 (0.45) | CASP3CASP7CASP1CASP9 | |
| SCHEMBL7542421 | 0.76 | CXCR2 (0.39) | — | |
| SCHEMBL6138062 | 0.76 | CXCR2 (0.45) | CASP3CASP7NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1161232-A4 | HYDROXY DIPHENYL UREA SULFONAMIDES AS IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2002-09-18 | — | — | EP | disclosed |
| EP-1161232-A1 | HYDROXY DIPHENYL UREA SULFONAMIDES AS IL-8 RECEPTOR ANTAGONISTS | SmithKline Beecham Corporation (US) | 2001-12-12 | — | — | EP | disclosed |
| WO-2000035442-A1 | HYDROXY DIPHENYL UREA SULFONAMIDES AS IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-06-22 | — | — | WO | disclosed |