Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | MITF | O75030 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7847132 | 0.89 | RAB9A (0.58) | HTTKDM4EMITFALDH1A1RAB9A | |
| SCHEMBL344964 | 0.84 | PPARG (0.54) | HTTKDM4EMITFALDH1A1RAB9A | |
| SCHEMBL5182644 | 0.81 | PLAAT3 (0.58) | KDM4EALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL585819 | 0.80 | FFAR4 (0.60) | HTTKDM4EMITFALDH1A1RAB9A | |
| SCHEMBL14935243 | 0.80 | IGF1R (0.47) | ALOX5 | |
| SCHEMBL15022767 | 0.80 | TUBB4A (0.48) | HTTKDM4EMITFALDH1A1CYP1A2 | |
| SCHEMBL584597 | 0.80 | TNKS2 (0.51) | HTTKDM4EMITFALDH1A1LMNA | |
| SCHEMBL28733753 | 0.80 | KDM4E (0.56) | KDM4ELMNAMAPK1CYP1A2CYP3A4 | |
| SCHEMBL1979399 | 0.80 | HTT (0.53) | HTTKDM4EMITFALDH1A1RAB9A | |
| SCHEMBL11222002 | 0.80 | PPARG (0.54) | HTTKDM4EMITFALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1257264-A4 | ESTROGEN RECEPTOR MODULATORS | MERCK & CO INC (US) | 2005-08-10 | — | — | EP | disclosed |
| EP-1257264-A1 | ESTROGEN RECEPTOR MODULATORS | Merck & Co., Inc. (US) | 2002-11-20 | — | — | EP | disclosed |
| WO-2001082923-A1 | ESTROGEN RECEPTOR MODULATORS | MERCK & CO., INC. (US) | 2001-11-08 | — | — | WO | disclosed |