SCHEMBL6137641

SCHEMBL6137641

CCOC(=O)c1sc(C(F)(F)F)nc1C(F)(F)F

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.52
HPGD P15428 3/20 0.52
KDM4E B2RXH2 3/20 0.47
MEN1 O00255 2/20 0.47
MAPT P10636 2/20 0.47
KMT2A Q03164 2/20 0.47
HSP90AA1 P07900 1/20 0.47
CRHBP P24387 1/20 0.47
CRHR2 Q13324 1/20 0.47
CYP1A2 P05177 1/20 0.45
P2RY1 P47900 1/20 0.43
LMNA P02545 1/20 0.42
DHODH Q02127 3/20 0.41
HDAC3 O15379 1/20 0.41
HDAC4 P56524 1/20 0.41
HDAC1 Q13547 1/20 0.41
HDAC6 Q9UBN7 1/20 0.41
TRPM8 Q7Z2W7 2/20 0.41
HSD17B10 Q99714 1/20 0.40
IDO1 P14902 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2362831 0.90 ALDH1A1 (0.49) ALDH1A1HPGDKDM4EMEN1MAPT
SCHEMBL8507216 0.86 ALDH1A1 (0.51) ALDH1A1HPGDKDM4EMEN1MAPT
SCHEMBL2145779 0.86 ALDH1A1 (0.54) ALDH1A1HPGDKDM4EMEN1MAPT
SCHEMBL15211255 0.86 ALDH1A1 (0.54) ALDH1A1HPGDKDM4EMEN1MAPT
SCHEMBL9750672 0.84 ALDH1A1 (0.52) ALDH1A1HPGDKDM4EMEN1MAPT
SCHEMBL10821105 0.84 ALDH1A1 (0.52) ALDH1A1HPGDKDM4EMEN1MAPT
SCHEMBL299362 0.84 ALDH1A1 (0.52) ALDH1A1HPGDKDM4EMEN1MAPT
SCHEMBL5628752 0.84 MAPT (0.60) ALDH1A1HPGDKDM4EMEN1MAPT
SCHEMBL31299633 0.84 ALDH1A1 (0.60) ALDH1A1HPGDKDM4EMEN1MAPT
SCHEMBL2150113 0.84 ALDH1A1 (0.49) ALDH1A1HPGDKDM4EMEN1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1110956-B1 The use of 5-carboxanilido-2,4-bis-trifluoromethylthiazoles to control rice blast DOW AGROSCIENCES LLC (US) 2005-02-23 EP disclosed
EP-1112688-B1 A method to control termites DOW AGROSCIENCES LLC (US) 2004-09-22 EP disclosed
US-6423730-B1 FLUORINATED TRIAZOLE RING CONTAINING COMPOUND DOW AGROSCIENCES LLC 2002-07-23 US disclosed
US-6372769-B1 APPLYING FUNGICIDES TO RICE DOW AGROSCIENCES LLC 2002-04-16 US disclosed
EP-1112688-A1 A method to control termites ROHM AND HAAS COMPANY (US) 2001-07-04 EP disclosed
EP-1110956-A1 5-carboxanilido-2,4-bis-trifluoromethylthiazoles and their use to control rice blast ROHM AND HAAS COMPANY (US) 2001-06-27 EP disclosed
EP-1110454-A2 5-Carboxanilido-haloalkylthiazoles as antimicrobial and marine antifouling agents ROHM AND HAAS COMPANY (US) 2001-06-27 EP disclosed
EP-1108714-A1 Microbicidal salts of 5-carboxanilido-haloalkylthiazoles ROHM AND HAAS COMPANY (US) 2001-06-20 EP disclosed