SCHEMBL299362

SCHEMBL299362

CCOC(=O)c1sc(Br)nc1C(F)(F)F

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.52
HPGD P15428 3/20 0.52
KDM4E B2RXH2 4/20 0.47
MAPT P10636 3/20 0.47
MEN1 O00255 2/20 0.47
KMT2A Q03164 2/20 0.47
HSP90AA1 P07900 1/20 0.47
CRHBP P24387 1/20 0.47
CRHR2 Q13324 1/20 0.47
CYP1A2 P05177 1/20 0.45
P2RY1 P47900 1/20 0.43
IDO1 P14902 1/20 0.42
LMNA P02545 1/20 0.42
DHODH Q02127 4/20 0.42
NPSR1 Q6W5P4 1/20 0.42
HDAC3 O15379 1/20 0.41
HDAC4 P56524 1/20 0.41
HDAC1 Q13547 1/20 0.41
HDAC6 Q9UBN7 1/20 0.41
TRPM8 Q7Z2W7 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL882483 0.88 ALDH1A1 (0.50) ALDH1A1HPGDKDM4EMAPTMEN1
SCHEMBL2145779 0.86 ALDH1A1 (0.54) ALDH1A1HPGDKDM4EMAPTMEN1
SCHEMBL9750672 0.84 ALDH1A1 (0.52) ALDH1A1HPGDKDM4EMAPTMEN1
SCHEMBL6137641 0.84 ALDH1A1 (0.52) ALDH1A1HPGDKDM4EMAPTMEN1
SCHEMBL10821105 0.84 ALDH1A1 (0.52) ALDH1A1HPGDKDM4EMAPTMEN1
SCHEMBL2150113 0.84 ALDH1A1 (0.49) ALDH1A1HPGDKDM4EMAPTMEN1
SCHEMBL244255 0.83 ALDH1A1 (0.76) ALDH1A1HPGDKDM4EMAPTMEN1
SCHEMBL8507216 0.83 ALDH1A1 (0.51) ALDH1A1HPGDKDM4EMAPTMEN1
SCHEMBL2309900 0.83 ALDH1A1 (0.51) ALDH1A1HPGDKDM4EMAPTMEN1
SCHEMBL3454323 0.83 ALDH1A1 (0.51) ALDH1A1HPGDKDM4EMAPTMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 63 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250320224-A1 NOVEL PAR-2 INHIBITORS DOMAIN THERAPEUTICS (FR) 2025-10-16 US disclosed
EP-4570313-A2 CYANOTRIAZOLE COMPOUNDS Otsuka Pharmaceutical Co., Ltd. (JP) 2025-06-18 EP disclosed
WO-2025085848-A1 ANTIBACTERIAL COMPOUNDS ARREPATH, INC. (US) 2025-04-24 WO disclosed
EP-4532496-A1 NOVEL PAR-2 INHIBITORS Domain Therapeutics (FR) 2025-04-09 EP disclosed
CN-112638898-B Heteroaryl substituted sulfonamide compounds and their use as sodium channel inhibitors 泽农医药公司 2024-04-09 CN disclosed
WO-2023233033-A1 NOVEL PAR-2 INHIBITORS DOMAIN THERAPEUTICS (FR) 2023-12-07 WO disclosed
EP-4219477-A1 CYANOTRIAZOLE COMPOUNDS Otsuka Pharmaceutical Co., Ltd. (JP) 2023-08-02 EP disclosed
US-11273154-B2 Azole compounds as ubiquitin-specific protease USP7 inhibitors PROGENRA, INC. (US) 2022-03-15 US disclosed
EP-3844158-A1 HETEROARYL-SUBSTITUTED SULFONAMIDE COMPOUNDS AND THEIR USE AS SODIUM CHANNEL INHIBITORS Xenon Pharmaceuticals Inc. (CA) 2021-07-07 EP disclosed
CN-112638898-A Heteroaryl substituted sulfonamide compounds and their use as sodium channel inhibitors 泽农医药公司 2021-04-09 CN disclosed
WO-2009012482-A2 5-MEMBERED HETEROCYCLIC AMIDES AND RELATED COMPOUNDS H.LUNDBECK A/S (DK) 2009-01-22 WO disclosed
WO-2009012482-A2 5-MEMBERED HETEROCYCLIC AMIDES AND RELATED COMPOUNDS H.LUNDBECK A/S (DK) 2009-01-22 WO disclosed
US-7273866-B2 2-aryl thiazole derivatives as KCNQ modulators BRISTOL-MYERS SQUIBB COMPANY (US) 2007-09-25 US disclosed
US-7273866-B2 2-aryl thiazole derivatives as KCNQ modulators BRISTOL-MYERS SQUIBB COMPANY (US) 2007-09-25 US disclosed
WO-2004060880-A1 AMINOALKYL THIAZOLE DERIVATIVES AS KCNQ MODULATORS BRISTOL-MYERS SQUIBB COMPANY (US) 2004-07-22 WO disclosed
US-4602937-A PLANT SAFENING AGENTS, ACETAMIDE HERBICIDE MONSANTO COMPANY (US) 1986-07-29 US disclosed
US-4602454-A PLANT SAFENING AGENTS, SEEDS CHLOROACETAMIDE HERBICIDES MONSANTO COMPANY (US) 1986-07-29 US disclosed
US-4437876-A PLANT SAFENING AGENTS FOR ACETAMIDE HERBICIDES MONSANTO COMPANY (US) 1984-03-20 US disclosed
US-4437875-A PLANT SAFENING AGENT FOR ACETAMIDE HERBICIDE MONSANTO COMPANY (US) 1984-03-20 US disclosed
US-4199506-A REDUCES HERBICIDAL INJURY TO PLATNS DUE TO ACETAMIDE HERBICIDES MONSANTO COMPANY (US) 1980-04-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11273154-B2 Azole compounds as ubiquitin-specific protease USP7 inhibitors USP7, USP1, USP2 ALDH1A1 2210/4885HPGD 3096/4885KDM4E 513/4885
US-20250320224-A1 NOVEL PAR-2 INHIBITORS F2RL1, F2R, F2RL3 ALDH1A1 1534/4885HPGD 249/4885KDM4E 4042/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.