Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3
The experimentally established mechanism targets of Oxedrine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A known ✓ | P35348 | 6/20 | 0.63 |
| ▸ | ADRA2C known ✓ | P18825 | 4/20 | 0.63 |
| ▸ | ADRA2A known ✓ | P08913 | 4/20 | 0.51 |
| ▸ | ADRB2 known ✓ | P07550 | 3/20 | 0.51 |
| ▸ | ADRB1 known ✓ | P08588 | 3/20 | 0.51 |
| ▸ | ADRA2B known ✓ | P18089 | 3/20 | 0.51 |
| ▸ | ADRA1B known ✓ | P35368 | 3/20 | 0.51 |
| ▸ | ADRB3 known ✓ | P13945 | 2/20 | 0.51 |
| ▸ | ADRA1D known ✓ | P25100 | 2/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 7/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.66 |
| ▸ | HTR1A | P08908 | 4/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.66 |
| ▸ | BLM | P54132 | 3/20 | 0.66 |
| ▸ | THPO | P40225 | 2/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.66 |
| ▸ | NMUR2 | Q9GZQ4 | 1/20 | 0.66 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenylephrine SCHEMBL5665418 | 0.86 | HIF1A (0.73) | HIF1AKDM4EHTR1AALDH1A1TDP1 | |
| Phenylephrine SCHEMBL18305612 | 0.85 | HIF1A (0.74) | HIF1AKDM4EHTR1AALDH1A1TDP1 | |
| Epinephrine SCHEMBL3904566 | 0.85 | KDM4E (0.68) | HIF1AKDM4EHTR1AALDH1A1TDP1 | |
| Racepinephrine SCHEMBL9227820 | 0.84 | KDM4E (0.69) | HIF1AKDM4EALDH1A1TDP1BLM | |
| Halostachine SCHEMBL28853304 | 0.83 | HIF1A (0.75) | HIF1AKDM4EHTR1AALDH1A1TDP1 | |
| Oxilofrine SCHEMBL5173040 | 0.81 | ADRA1A (0.67) | HIF1AKDM4EHTR1AALDH1A1TDP1 | |
| Oxilofrine SCHEMBL14465574 | 0.81 | ADRA1A (0.67) | HIF1AKDM4EHTR1AALDH1A1TDP1 | |
| Oxilofrine SCHEMBL4256893 | 0.81 | ADRA1A (0.67) | HIF1AKDM4EHTR1AALDH1A1TDP1 | |
| Oxilofrine SCHEMBL147458 | 0.81 | ADRA1A (0.67) | HIF1AKDM4EHTR1AALDH1A1TDP1 | |
| Oxilofrine SCHEMBL14153976 | 0.81 | ADRA1A (0.67) | HIF1AKDM4EHTR1AALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1383537-A4 | NOVEL CHOCOLATE COMPOSITION AS DELIVERY SYSTEM FOR NUTRIENTS AND MEDICATIONS | ALTAFFER PAULO (US) | 2005-09-14 | — | — | EP | disclosed |
| EP-1383537-A1 | NOVEL CHOCOLATE COMPOSITION AS DELIVERY SYSTEM FOR NUTRIENTS AND MEDICATIONS | Altaffer, Paulo (US) | 2004-01-28 | — | — | EP | disclosed |
| WO-2002078746-A1 | NOVEL CHOCOLATE COMPOSITION AS DELIVERY SYSTEM FOR NUTRIENTS AND MEDICATIONS | ALTAFFER, PAULO (US) | 2002-10-10 | — | — | WO | disclosed |