Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3
The experimentally established mechanism targets of Racepinephrine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 6/20 | 0.69 |
| ▸ | ADRB1 known ✓ | P08588 | 5/20 | 0.67 |
| ▸ | ADRB3 known ✓ | P13945 | 4/20 | 0.67 |
| ▸ | ADRA1A known ✓ | P35348 | 3/20 | 0.67 |
| ▸ | ADRA2C known ✓ | P18825 | 3/20 | 0.67 |
| ▸ | ADRA1D known ✓ | P25100 | 2/20 | 0.67 |
| ▸ | ADRA1B known ✓ | P35368 | 2/20 | 0.67 |
| ▸ | ADRA2A known ✓ | P08913 | 2/20 | 0.67 |
| ▸ | ADRA2B known ✓ | P18089 | 2/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.69 |
| ▸ | BLM | P54132 | 4/20 | 0.69 |
| ▸ | PMP22 | Q01453 | 3/20 | 0.69 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.69 |
| ▸ | TDP1 | Q9NUW8 | 7/20 | 0.67 |
| ▸ | MAPT | P10636 | 7/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.67 |
| ▸ | TSHR | P16473 | 5/20 | 0.67 |
| ▸ | MEN1 | O00255 | 4/20 | 0.67 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Epinephrine SCHEMBL3904566 | 0.99 | KDM4E (0.68) | KDM4EADRB2BLMPMP22NPSR1 | |
| Racepinephrine SCHEMBL28217990 | 0.86 | KDM4E (0.93) | KDM4EADRB2BLMPMP22NPSR1 | |
| Phenylephrine SCHEMBL18305612 | 0.86 | HIF1A (0.74) | KDM4EADRB2BLMPMP22NPSR1 | |
| Racepinephrine SCHEMBL28025377 | 0.85 | KDM4E (0.93) | KDM4EADRB2BLMPMP22NPSR1 | |
| Phenylephrine SCHEMBL5665418 | 0.84 | HIF1A (0.73) | KDM4EADRB2BLMPMP22NPSR1 | |
| Oxedrine SCHEMBL6137715 | 0.84 | HIF1A (0.66) | KDM4EADRB2BLMPMP22NPSR1 | |
| Epinephrine SCHEMBL6536046 | 0.83 | KDM4E (0.90) | KDM4EADRB2BLMPMP22NPSR1 | |
| Racepinephrine SCHEMBL6536048 | 0.83 | KDM4E (0.90) | KDM4EADRB2BLMPMP22NPSR1 | |
| L-Adrenaline SCHEMBL4983607 | 0.83 | KDM4E (1.00) | KDM4EADRB2BLMPMP22NPSR1 | |
| Epinephrine SCHEMBL4980185 | 0.83 | KDM4E (1.00) | KDM4EADRB2BLMPMP22NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0452837-B1 | Adhesive device for transdermal administration of an active agent | NITTO DENKO CORP (JP) | 1995-08-16 | — | — | EP | disclosed |
| US-5176916-A | Plaster layer containing a medicinal ingredient, hydrophobic polymer, absorption promoter, water and a hydrophilic polymer | NITTO ELECTRIC INDUSTRIAL CO., LTD. (JP) | 1993-01-05 | — | — | US | disclosed |
| EP-0452837-A2 | Adhesive device for transdermal administration of an active agent | NITTO DENKO CORPORATION (JP) | 1991-10-23 | — | — | EP | disclosed |