Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN5A | Q14524 | 8/20 | 0.62 |
| ▸ | SCN2A | Q99250 | 8/20 | 0.62 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.56 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.43 |
| ▸ | SCNN1A | P37088 | 1/20 | 0.41 |
| ▸ | HRH2 | P25021 | 3/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4628720 | 0.81 | SCN5A (0.93) | SCN5ASCN2ASCNN1A | |
| SCHEMBL8003305 | 0.73 | HRH4 (0.49) | HRH4HRH2HRH3 | |
| SCHEMBL4627543 | 0.72 | SMN1; SMN2 (0.64) | SCN5ASCN2AHRH4 | |
| SCHEMBL28337263 | 0.71 | TBXAS1 (0.47) | HRH4PKM | |
| SCHEMBL4627536 | 0.71 | SCN5A (0.64) | SCN5ASCN2AMALT1 | |
| Sulfuric Acid SCHEMBL11660447 | 0.70 | HRH4 (0.47) | HRH4HRH2HRH3 | |
| SCHEMBL8619886 | 0.67 | HRH4 (0.61) | HRH4HRH3 | |
| SCHEMBL11781626 | 0.66 | RAB9A (0.56) | PKM | |
| SCHEMBL29073999 | 0.65 | CA2 (0.53) | SCN5ASCN2APKM | |
| SCHEMBL4763275 | 0.65 | TBXAS1 (0.65) | HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1032556-A4 | PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHODS OF USE | CAMBRIDGE NEUROSCIENCE INC (US) | 2005-02-02 | — | — | EP | disclosed |
| EP-1032556-A1 | PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHODS OF USE | CAMBRIDGE NEUROSCIENCE, INC. (US) | 2000-09-06 | — | — | EP | disclosed |
| WO-1999020599-A1 | PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHODS OF USE | CAMBRIDGE NEUROSCIENCE, INC. (US) | 1999-04-29 | — | — | WO | disclosed |