SCHEMBL6137836

SCHEMBL6137836

Cc1ccccc1C(=O)N(C(=N)N)c1ccc(C(C)C)cc1

nearest known ligand 0.43

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
TRPM8 Q7Z2W7 1/20 0.42
ESRRA P11474 1/20 0.40
KMT2A Q03164 2/20 0.40
ALDH1A1 P00352 1/20 0.38
UTS2R Q9UKP6 1/20 0.37
KIF11 P52732 1/20 0.36
TSHR P16473 1/20 0.36
MAPK1 P28482 1/20 0.36
CYP1A2 P05177 1/20 0.36
CYP2D6 P10635 1/20 0.36
CYP2C19 P33261 1/20 0.36
TP53 P04637 1/20 0.36
LMNA P02545 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6137957 0.78 TRPM8 (0.40) TRPM8KMT2AALDH1A1TSHRMAPK1
SCHEMBL6869180 0.73 KMT2A (0.47) TRPM8KMT2AALDH1A1TSHRMAPK1
SCHEMBL15741955 0.71 KMT2A (0.46) TRPM8KMT2AALDH1A1TSHRMAPK1
Boric Acid SCHEMBL8170320 0.69 KMT2A (0.44) TRPM8KMT2AALDH1A1TSHRMAPK1
SCHEMBL17660206 0.68 HPGD (0.70) KMT2AALDH1A1MAPK1LMNA
SCHEMBL27706137 0.68 SMN1; SMN2 (0.42) KMT2AALDH1A1TSHRMAPK1TP53
SCHEMBL4629385 0.68 SMN1; SMN2 (0.51) KMT2AALDH1A1LMNA
SCHEMBL8419196 0.67 HTT (0.45) ALDH1A1KIF11
SCHEMBL4629388 0.67 SCN2A (0.64) KMT2AALDH1A1CYP1A2CYP2D6CYP2C19
SCHEMBL3368840 0.66 F2 (0.44) KMT2AALDH1A1TSHRCYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1032556-A4 PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHODS OF USE CAMBRIDGE NEUROSCIENCE INC (US) 2005-02-02 EP claimed
EP-1032556-A1 PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHODS OF USE CAMBRIDGE NEUROSCIENCE, INC. (US) 2000-09-06 EP claimed
WO-1999020599-A1 PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHODS OF USE CAMBRIDGE NEUROSCIENCE, INC. (US) 1999-04-29 WO claimed
EP-1032556-A4 PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHODS OF USE CAMBRIDGE NEUROSCIENCE INC (US) 2005-02-02 EP disclosed
EP-1032556-A1 PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHODS OF USE CAMBRIDGE NEUROSCIENCE, INC. (US) 2000-09-06 EP disclosed
WO-1999020599-A1 PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHODS OF USE CAMBRIDGE NEUROSCIENCE, INC. (US) 1999-04-29 WO disclosed