Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PLK1 | P53350 | 1/20 | 0.33 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.33 |
| ▸ | PLK2 | Q9NYY3 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6137836 | 0.78 | TRPM8 (0.42) | TRPM8KMT2ATSHRMAPK1ALDH1A1 | |
| SCHEMBL6137876 | 0.74 | PARP10 (0.47) | KMT2AMAPK1ALDH1A1NPC1RAB9A | |
| SCHEMBL6869180 | 0.73 | KMT2A (0.47) | TRPM8KMT2ATSHRMAPK1ALDH1A1 | |
| SCHEMBL9627587 | 0.71 | SIGMAR1 (0.42) | KMT2ATSHRSIGMAR1SLC6A2 | |
| SCHEMBL12989218 | 0.69 | KMT2A (0.50) | TRPM8KMT2ATSHRMAPK1NPC1 | |
| Boric Acid SCHEMBL8170320 | 0.69 | KMT2A (0.44) | TRPM8KMT2ATSHRMAPK1ALDH1A1 | |
| SCHEMBL27365885 | 0.69 | SIGMAR1 (0.44) | TRPM8TSHRALDH1A1SIGMAR1MAPT | |
| SCHEMBL10615591 | 0.68 | ALDH1A1 (0.35) | KMT2ATSHRMAPK1ALDH1A1SLC6A2 | |
| SCHEMBL20628407 | 0.67 | KMT2A (0.45) | TRPM8KMT2ATSHRMAPK1ALDH1A1 | |
| SCHEMBL31632660 | 0.67 | IRAK4 (0.55) | KMT2ATSHRALDH1A1SLC6A2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1032556-A4 | PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHODS OF USE | CAMBRIDGE NEUROSCIENCE INC (US) | 2005-02-02 | — | — | EP | disclosed |
| EP-1032556-A1 | PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHODS OF USE | CAMBRIDGE NEUROSCIENCE, INC. (US) | 2000-09-06 | — | — | EP | disclosed |
| WO-1999020599-A1 | PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHODS OF USE | CAMBRIDGE NEUROSCIENCE, INC. (US) | 1999-04-29 | — | — | WO | disclosed |