SCHEMBL6137841

SCHEMBL6137841

CCCCC1c2c(cc(F)c(OC)c2Cl)C2=CC(=O)CCC21

nearest known ligand 0.32

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
CRBN Q96SW2 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6137378 0.79
SCHEMBL6137844 0.75 ALDH1A1 (0.32)
SCHEMBL4853543 0.70 CYP24A1 (0.33) CRBN
SCHEMBL2419510 0.68 MEN1 (0.31)
SCHEMBL6152154 0.63 DRD3 (0.32)
SCHEMBL6313142 0.63 ESR1 (0.32)
SCHEMBL2417565 0.62 ESR2 (0.55)
SCHEMBL5904516 0.62 ESR2 (0.55)
SCHEMBL6137382 0.62
SCHEMBL4849090 0.62 ESR2 (0.52)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1257264-A4 ESTROGEN RECEPTOR MODULATORS MERCK & CO INC (US) 2005-08-10 EP disclosed
EP-1257264-A1 ESTROGEN RECEPTOR MODULATORS Merck & Co., Inc. (US) 2002-11-20 EP disclosed
WO-2001082923-A1 ESTROGEN RECEPTOR MODULATORS MERCK & CO., INC. (US) 2001-11-08 WO disclosed