Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 3/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6138493 | 0.88 | OPRM1 (0.39) | OPRM1OPRL1LMNAKMT2A | |
| SCHEMBL6138453 | 0.86 | OPRM1 (0.38) | OPRM1OPRL1 | |
| SCHEMBL2334139 | 0.71 | OPRM1 (0.42) | OPRM1OPRL1KMT2A | |
| SCHEMBL3763074 | 0.71 | NPC1 (0.36) | LMNAKMT2A | |
| SCHEMBL6138328 | 0.69 | CYP2C19 (0.38) | OPRM1OPRL1LMNAKMT2A | |
| SCHEMBL6138317 | 0.67 | — | — | |
| SCHEMBL11636875 | 0.67 | CXCR3 (0.45) | KMT2A | |
| SCHEMBL26461937 | 0.67 | — | — | |
| SCHEMBL21815374 | 0.66 | NOS3 (0.38) | — | |
| SCHEMBL28903229 | 0.66 | NOS3 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1170281-B1 | 1,1- and 1,2-disubstituted cyclopropanes, process for their preparation and pharmaceutical compositions thereof | SERVIER LAB (FR) | 2005-12-21 | — | — | EP | claimed |
| JP-2002069046-A | NEW 1,1- AND 1,2-DISUBSTITUTED CYCLOPROPANE COMPOUND, METHOD FOR PRODUCING THE SAME AND MEDICINAL COMPOSITION CONTAINING THE SAME | LAB SERVIER | 2002-03-08 | — | — | JP | disclosed |