SCHEMBL6138312

SCHEMBL6138312

C#Cc1ccc(-c2ccccc2)c(C)c1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR2 Q92731 1/20 0.53
GABRA1 P14867 3/20 0.40
GABRA5 P31644 3/20 0.40
GABRA2 P47869 3/20 0.40
GABRB2 P47870 3/20 0.40
GABRA3 P34903 2/20 0.40
GABRG2 P18507 1/20 0.40
GABRB3 P28472 1/20 0.40
CYP2A6 P11509 2/20 0.38
CYP2B6 P20813 1/20 0.38
PPARG P37231 1/20 0.37
PPARA Q07869 1/20 0.37
PDE3B Q13370 1/20 0.36
PDE3A Q14432 1/20 0.36
KDM4E B2RXH2 1/20 0.36
GALR3 O60755 1/20 0.36
ALDH1A1 P00352 1/20 0.36
GAA P10253 1/20 0.36
HPGD P15428 1/20 0.36
BACE1 P56817 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3800243 0.82 GABRA1 (0.42) ESR2GABRA1GABRA5GABRA2GABRB2
SCHEMBL2572264 0.81 ESR2 (0.53) ESR2KDM4EGALR3ALDH1A1GAA
SCHEMBL7608202 0.78 GABRA1 (0.40) GABRA1GABRA5GABRA2GABRB2GABRA3
SCHEMBL10659983 0.78 GABRA1 (0.38) ESR2GABRA1GABRA5GABRA2GABRB2
SCHEMBL28757167 0.77 ALDH1A1 (0.48) GABRA1GABRA5GABRA2GABRB2GABRA3
SCHEMBL9303383 0.77 PTGS1 (0.42) GABRA1GABRA5GABRA2GABRB2GABRA3
SCHEMBL9420892 0.77 CYP2A6 (0.54) GABRA1GABRA5GABRA2GABRB2GABRA3
SCHEMBL3543615 0.77 ESR2 (0.38) ESR2GAA
SCHEMBL28641198 0.77 GABRA1 (0.40) ESR2GABRA1GABRA5GABRA2GABRB2
SCHEMBL11308138 0.77 CYP1A1 (0.46) GABRA1GABRA5GABRA2GABRB2GABRA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1199301-B1 Olefination process to itaconate and succinate derivatives PFIZER LTD (GB) 2005-06-08 EP claimed
US-4301313-A ANTIINFLAMMATORY AGENTS, ANTIPYRETICS, ANALGESICS ELI-LILLY AND COMPANY (US) 1981-11-17 US claimed
US-4267388-A BY SULFONATING A BENZYL ALCOHOL COMPOUND, REDUCING THE SULFONYL DERIVATIVE TO A HALOSTYRENYL COMPOUND, AND DEHYDROHALOGENATING TO THE ETHYNYLBENZENE WILLIAM H. RORER, INC. (US) 1981-05-12 US claimed
US-4301313-A ANTIINFLAMMATORY AGENTS, ANTIPYRETICS, ANALGESICS ELI-LILLY AND COMPANY (US) 1981-11-17 US disclosed
US-4267388-A BY SULFONATING A BENZYL ALCOHOL COMPOUND, REDUCING THE SULFONYL DERIVATIVE TO A HALOSTYRENYL COMPOUND, AND DEHYDROHALOGENATING TO THE ETHYNYLBENZENE WILLIAM H. RORER, INC. (US) 1981-05-12 US disclosed
US-4226887-A P-BIPHENYLYLACETYLENE ELI LILLY AND COMPANY (US) 1980-10-07 US disclosed
US-3991212-A PHENYLACETYLENE COMPOUNDS ELI LILLY AND COMPANY (US) 1976-11-09 US disclosed
US-3968251-A Arylacetylene compounds as antithrombotic agents ELI LILLY AND COMPANY (US) 1976-07-06 US disclosed