⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2311068 | 0.90 | LMNA (0.34) | — | |
| SCHEMBL24996651 | 0.78 | CYP2D6 (0.40) | — | |
| SCHEMBL20781995 | 0.77 | OPRM1 (0.33) | — | |
| SCHEMBL6137914 | 0.73 | DPP4 (0.31) | — | |
| SCHEMBL24995118 | 0.73 | — | — | |
| SCHEMBL2324364 | 0.69 | OPRM1 (0.31) | — | |
| SCHEMBL7603960 | 0.63 | — | — | |
| SCHEMBL18583709 | 0.63 | SLC6A4 (0.35) | — | |
| SCHEMBL3999046 | 0.63 | — | — | |
| SCHEMBL6138301 | 0.63 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1170281-B1 | 1,1- and 1,2-disubstituted cyclopropanes, process for their preparation and pharmaceutical compositions thereof | SERVIER LAB (FR) | 2005-12-21 | — | — | EP | disclosed |
| US-6943184-B2 | 1,1- and 1,2-disubstituted cyclopropane compounds | LES LABORATORIES SERVIER (FR) | 2005-09-13 | — | — | US | disclosed |
| CN-1176066-C | 1,1-and 1,2-twice subsitituted cyclopropane compound, preparation method thereof and drug composite containing their | ɪά��ʵ���� | 2004-11-17 | — | — | CN | disclosed |
| US-20020022643-A1 | 1,1- and 1,2-disubstituted cyclopropane compounds | ADIR ET COMPAGNIE (FR) | 2002-02-21 | — | — | US | disclosed |
| EP-1170281-A1 | 1,1- and 1,2-disubstituted cyclopropanes, process for their preparation and pharmaceutical compositions thereof | LES LABORATOIRES SERVIER (FR) | 2002-01-09 | — | — | EP | disclosed |
| CN-1330067-A | 1,1-and 1,2-twice subsitituted cyclopropane compound, preparation method thereof and drug composite containing their | ADIR (FR) | 2002-01-09 | — | — | CN | disclosed |