Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Monoethanolamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 3/20 | 0.71 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.66 |
| ▸ | NAAA | Q02083 | 1/20 | 0.54 |
| ▸ | SLC6A5 | Q9Y345 | 2/20 | 0.50 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.49 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.49 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.49 |
| ▸ | CASP2 | P42575 | 1/20 | 0.49 |
| ▸ | EPHX1 | P07099 | 5/20 | 0.48 |
| ▸ | CES2 | O00748 | 3/20 | 0.48 |
| ▸ | CES1 | P23141 | 3/20 | 0.48 |
| ▸ | RRM1 | P23921 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Monoethanolamine SCHEMBL6138913 | 1.00 | PLA2G2A (0.71) | PLA2G2APLA2G4ANAAASLC6A5GNAI3 | |
| SCHEMBL10062565 | 0.86 | PLA2G2A (0.71) | PLA2G2APLA2G4ANAAACES2CES1 | |
| SCHEMBL12636328 | 0.86 | PLA2G2A (0.79) | PLA2G2APLA2G4ANAAACASP2EPHX1 | |
| Monoethanolamine SCHEMBL6139295 | 0.83 | NAAA (0.73) | NAAASLC6A5CASP2EPHX2 | |
| SCHEMBL28776220 | 0.83 | PLA2G2A (1.00) | PLA2G2APLA2G4AEPHX2 | |
| Monoethanolamine SCHEMBL28044583 | 0.83 | NAAA (0.73) | NAAASLC6A5CASP2EPHX2 | |
| Monoethanolamine SCHEMBL6139219 | 0.83 | NAAA (0.73) | NAAASLC6A5CASP2EPHX2 | |
| SCHEMBL29449856 | 0.81 | PLA2G4A (0.73) | PLA2G2APLA2G4ANAAACASP2EPHX1 | |
| SCHEMBL30439276 | 0.81 | PLA2G2A (0.67) | PLA2G2APLA2G4ANAAACASP2EPHX1 | |
| SCHEMBL1877382 | 0.79 | PLA2G4A (1.00) | PLA2G2APLA2G4AEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1370241-B1 | MULTI-LAMELLAR EMULSION(MLE) FOR STABILIZING DERMATOLOGICALLY USEFUL INGREDIENTS AND EXTERNAL BASE PREPARATIONS FOR GENERAL SKIN DISEASES UTILIZING THE SAME | NEOPHARM CO LTD (KR) | 2012-11-21 | — | — | EP | disclosed |
| EP-1370241-A4 | MULTI-LAMELLAR EMULSION(MLE) FOR STABILIZING DERMATOLOGICALLY USEFUL INGREDIENTS AND EXTERNAL BASE PREPARATIONS FOR GENERAL SKIN DISEASES UTILIZING THE SAME | NEOPHARM CO LTD (KR) | 2005-01-26 | — | — | EP | disclosed |
| EP-1370241-A1 | MULTI-LAMELLAR EMULSION(MLE) FOR STABILIZING DERMATOLOGICALLY USEFUL INGREDIENTS AND EXTERNAL BASE PREPARATIONS FOR GENERAL SKIN DISEASES UTILIZING THE SAME | Neopharm Co., Ltd. (KR) | 2003-12-17 | — | — | EP | disclosed |
| WO-2002067900-A1 | MULTI-LAMELLAR EMULSION(MLE) FOR STABILIZING DERMATOLOGICALLY USEFUL INGREDIENTS AND EXTERNAL BASE PREPARATIONS FOR GENERAL SKIN DISEASES UTILIZING THE SAME | NEOPHARM CO., LTD. (KR) | 2002-09-06 | — | — | WO | disclosed |