Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | PDE4A | P27815 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26005660 | 0.84 | MAPT (0.63) | HTR6MAPTDRD3TP53POLB | |
| SCHEMBL6139242 | 0.79 | CYP11B1 (0.55) | MAPTPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL2074679 | 0.79 | DRD3 (0.62) | HTR6MAPTDRD3MEN1KMT2A | |
| SCHEMBL5674794 | 0.78 | APEX1 (0.56) | HTR6MAPTTSHRPDE4APDE4B | |
| SCHEMBL18363030 | 0.77 | TP53 (0.62) | HTR6MAPTMEN1KMT2ATP53 | |
| SCHEMBL1396337 | 0.77 | CYP11B1 (0.53) | HTR6MAPTDRD3MEN1KMT2A | |
| SCHEMBL6168586 | 0.77 | HTR6 (0.56) | HTR6TSHRDRD3 | |
| SCHEMBL6167735 | 0.76 | ALDH1A1 (0.53) | HTR6MAPTTSHRALDH1A1PKM | |
| SCHEMBL288153 | 0.75 | NPC1 (0.62) | TSHRPKMSMN1; SMN2MEN1KMT2A | |
| SCHEMBL5401651 | 0.74 | GAA (0.58) | HTR6PKMSMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1519919-A1 | INDOLIN PHENYLSULFONAMIDE DERIVATIVES | Bayer HealthCare AG (DE) | 2005-04-06 | — | — | EP | disclosed |
| WO-2004005253-A1 | INDOLIN PHENYLSULFONAMIDE DERIVATIVES | BAYER HEALTHCARE AG (DE) | 2004-01-15 | — | — | WO | disclosed |