Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | RORC | P51449 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HTR6 | P50406 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 4/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6168062 | 0.85 | ALDH1A1 (0.72) | ALDH1A1SMN1; SMN2TSHRUSP2PKM | |
| SCHEMBL6168586 | 0.82 | HTR6 (0.56) | TSHRHTR6 | |
| SCHEMBL29295623 | 0.81 | NOTUM (0.53) | ALDH1A1MAPT | |
| SCHEMBL6330427 | 0.78 | ALDH1A1 (0.69) | ALDH1A1SMN1; SMN2TSHRGAAUSP2 | |
| SCHEMBL26005660 | 0.78 | MAPT (0.63) | MAPTHTR6TP53POLBLMNA | |
| SCHEMBL6139327 | 0.76 | HTR6 (0.49) | ALDH1A1SMN1; SMN2TSHRMAPTHTR6 | |
| SCHEMBL2074679 | 0.75 | DRD3 (0.62) | MAPTRORCHTR6 | |
| SCHEMBL4035842 | 0.75 | PNMT (0.49) | ALDH1A1SMN1; SMN2RORCGAAMAPK1 | |
| SCHEMBL6349185 | 0.74 | MAPT (0.49) | SMN1; SMN2MAPTHTR6USP2PKM | |
| SCHEMBL4040738 | 0.73 | NOTUM (0.47) | ALDH1A1SMN1; SMN2GAAMAPK1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1392316-B1 | BENZO[D]AZEPINE DERIVATIVES AS 5-HT6 RECEPTOR ANTAGONISTS. | SMITHKLINE BEECHAM PLC (GB) | 2005-04-20 | — | — | EP | disclosed |
| US-20040192671-A1 | Benzo[d]azepine derivatives as 5-ht6 receptor anatagonists | SMITHKLINE BEECHAM P.L.C. (GB) | 2004-09-30 | — | — | US | disclosed |
| EP-1392316-A1 | BENZO[D]AZEPINE DERIVATIVES AS 5-HT6 RECEPTOR ANTAGONISTS. | SMITHKLINE BEECHAM PLC (GB) | 2004-03-03 | — | — | EP | disclosed |
| WO-2002089811-A1 | BENZO[D]AZEPINE DERIVATIVES AS 5-HT6 RECEPTOR ANTAGONISTS. | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-11-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040192671-A1 | Benzo[d]azepine derivatives as 5-ht6 receptor anatagonists | HTR6, HTR5A, HTR1A | ALDH1A1 1942/4885SMN1; SMN2 2084/4885TSHR 319/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.