Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 7/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.35 |
| ▸ | LMNA | P02545 | 4/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 4/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6139529 | 1.00 | MAPT (0.44) | MAPTALDH1A1PKMMEN1KMT2A | |
| SCHEMBL2559234 | 0.75 | CES2 (0.44) | MAPTALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL2559511 | 0.75 | CES2 (0.44) | MAPTALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL2559233 | 0.75 | CES2 (0.44) | MAPTALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL320780 | 0.75 | MAPT (0.55) | MAPTALDH1A1PKMMEN1KMT2A | |
| SCHEMBL2559262 | 0.72 | CES2 (0.46) | MAPTALDH1A1LMNAHPGDCYP1A2 | |
| SCHEMBL8338715 | 0.72 | CES2 (0.46) | MAPTALDH1A1LMNAHPGDCYP1A2 | |
| SCHEMBL2559260 | 0.72 | CES2 (0.46) | MAPTALDH1A1LMNAHPGDCYP1A2 | |
| SCHEMBL177140 | 0.71 | TSHR (0.65) | MAPTALDH1A1PKMMEN1KMT2A | |
| SCHEMBL29952754 | 0.70 | PARP1 (0.50) | MAPTALDH1A1MEN1KMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1196403-B1 | ANTIPSYCHOTIC CYCLIC N-ARALKYL AMINES | SANOFI AVENTIS (FR) | 2005-11-09 | — | — | EP | disclosed |
| CN-1210250-C | Benzene derivatives, preparation method and pharmaceutical compositions containing same | SANOFI SYNTHELABO (FR) | 2005-07-13 | — | — | CN | disclosed |
| US-6908914-B1 | Antipsychotic cyclic N-aralkylamines | SANOFI-SYNTHELABO (FR) | 2005-06-21 | — | — | US | disclosed |
| CN-1156462-C | Antipsychotic cyclic N-aralkyl amines | ʥŵ��-�ϳ�ʵ���ҹ�˾ | 2004-07-07 | — | — | CN | disclosed |
| EP-1192122-B1 | BENZENE DERIVATIVES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SANOFI SYNTHELABO (FR) | 2003-10-22 | — | — | EP | disclosed |
| US-6482986-B1 | Benzene derivatives, preparation method and pharmaceutical compositions containing same | SANOFI-SYNTHELABO (FR) | 2002-11-19 | — | — | US | disclosed |
| CN-1367783-A | Antipsychotic cyclic N-aralkyl amines | SANOFI SYNTHELABO (FR) | 2002-09-04 | — | — | CN | disclosed |
| CN-1355782-A | Benzene derivatives, preparation method and pharmaceutical compositions containing same | SANOFI SYNTHELABO (FR) | 2002-06-26 | — | — | CN | disclosed |
| EP-1196403-A1 | ANTIPSYCHOTIC CYCLIC N-ARALKYL AMINES | Sanofi-Aventis (FR) | 2002-04-17 | — | — | EP | disclosed |
| EP-1192122-A1 | BENZENE DERIVATIVES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SANOFI-SYNTHELABO (FR) | 2002-04-03 | — | — | EP | disclosed |
| WO-2001002380-A1 | ANTIPSYCHOTIC CYCLIC N-ARALKYL AMINES | SANOFI-SYNTHELABO (FR) | 2001-01-11 | — | — | WO | disclosed |
| WO-2000076953-A1 | BENZENE DERIVATIVES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SANOFI-SYNTHELABO (FR) | 2000-12-21 | — | — | WO | disclosed |