Acetic Acid

Acetic Acid

SCHEMBL6139766

CC(=O)O.CCCc1ccc(C(N)=O)c(CCC)c1C(N)=O

nearest known ligand 0.41

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PRKCI P41743 1/20 0.41
CA12 O43570 1/20 0.38
MEN1 O00255 1/20 0.35
ALDH1A1 P00352 1/20 0.35
KMT2A Q03164 1/20 0.35
HSD17B10 Q99714 1/20 0.35
PTPN1 P18031 1/20 0.34
PTPN11 Q06124 1/20 0.34
CNR2 P34972 1/20 0.33
CYSLTR2 Q9NS75 1/20 0.32
CYSLTR1 Q9Y271 1/20 0.32
LDHA P00338 1/20 0.32
LDHB P07195 1/20 0.32
LMNA P02545 1/20 0.32
CYP1A2 P05177 1/20 0.32
MAPT P10636 1/20 0.32
CYP2C9 P11712 1/20 0.32
NFKB1 P19838 1/20 0.32
PPARG P37231 1/20 0.32
BLM P54132 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2206844 0.95 PRKCI (0.40) PRKCICA12MEN1ALDH1A1KMT2A
Hydrochloric Acid SCHEMBL3355963 0.94 PRKCI (0.39) PRKCICA12MEN1ALDH1A1KMT2A
Hydrochloric Acid SCHEMBL3352601 0.94 PRKCI (0.39) PRKCICA12MEN1ALDH1A1KMT2A
Formamide SCHEMBL6342969 0.89 PRKCI (0.36) PRKCICA12MEN1ALDH1A1KMT2A
SCHEMBL5349926 0.89 PRKCI (0.38) PRKCICA12PTPN1PTPN11LDHA
Trifluoroacetic Acid SCHEMBL6647805 0.88 PRKCI (0.34) PRKCICA12MEN1ALDH1A1KMT2A
SCHEMBL7123990 0.82 PRKCI (0.40) PRKCICA12MEN1ALDH1A1KMT2A
SCHEMBL6187624 0.82 ALDH1A1 (0.37) PRKCICA12MEN1ALDH1A1KMT2A
SCHEMBL6675902 0.81 BID (0.43) MEN1ALDH1A1KMT2AHSD17B10CNR2
SCHEMBL11221193 0.80 PPARA (0.46) MEN1ALDH1A1KMT2AHSD17B10LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1503980-A2 SUBSTITUTED HYDROXYETHYLAMINES Elan Pharmaceuticals, Inc. (US) 2005-02-09 EP disclosed
EP-1453789-A2 N,N'-SUBSTITUTED-1,3-DIAMINO-2-HYDROXYPROPANE DERIVATIVES Elan Pharmaceuticals, Inc. (US) 2004-09-08 EP disclosed
WO-2003072535-A2 SUBSTITUTED HYDROXYETHYLAMINES ELAN PHARMACEUTICALS, INC. (US) 2003-09-04 WO disclosed
WO-2003040096-A2 N, N'-SUBSTITUTED-1,3-DIAMINO-2-HYDROXYPROPANE DERIVATIVES ELAN PHARMACEUTICALS, INC. (US) 2003-05-15 WO disclosed