Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | DHODH | Q02127 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.46 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.46 |
| ▸ | KMO | O15229 | 1/20 | 0.45 |
| ▸ | MLYCD | O95822 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.43 |
| ▸ | CTSD | P07339 | 1/20 | 0.43 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7055563 | 0.88 | DHODH (0.56) | TP53HPGDDHODHALDH1A1MAPT | |
| SCHEMBL3350034 | 0.85 | HPGD (0.55) | HPGDALDH1A1GAALMNASMN1; SMN2 | |
| SCHEMBL12497385 | 0.84 | HPGD (0.57) | TP53HPGDALDH1A1MAPTGAA | |
| SCHEMBL28149291 | 0.82 | ALDH1A1 (0.74) | TP53HPGDALDH1A1MAPTGAA | |
| SCHEMBL3351273 | 0.82 | P2RY14 (0.47) | TP53HPGDGABRA1GABRB2MLYCD | |
| SCHEMBL6139420 | 0.82 | SMN1; SMN2 (0.49) | HPGDALDH1A1MAPTGAASMN1; SMN2 | |
| SCHEMBL14376244 | 0.81 | CA12 (0.50) | TP53HPGDALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL2953707 | 0.81 | TPMT (0.53) | TP53HPGDLMNASMN1; SMN2GABRA1 | |
| SCHEMBL3886133 | 0.81 | MLYCD (0.45) | TP53HPGDALDH1A1SMN1; SMN2GABRA1 | |
| SCHEMBL3352183 | 0.81 | MLYCD (0.45) | TP53HPGDMAPTLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1503980-A2 | SUBSTITUTED HYDROXYETHYLAMINES | Elan Pharmaceuticals, Inc. (US) | 2005-02-09 | — | — | EP | disclosed |
| WO-2003072535-A2 | SUBSTITUTED HYDROXYETHYLAMINES | ELAN PHARMACEUTICALS, INC. (US) | 2003-09-04 | — | — | WO | disclosed |