Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 6/20 | 0.56 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | CTSD | P07339 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.44 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.44 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.43 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.43 |
| ▸ | MLYCD | O95822 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6139869 | 0.88 | TP53 (0.51) | DHODHHPGDGAAALDH1A1MAPT | |
| SCHEMBL3352714 | 0.86 | MLYCD (0.49) | HPGDALDH1A1TP53LMNACTSD | |
| SCHEMBL6894849 | 0.86 | MLYCD (0.49) | HPGDALDH1A1TP53LMNACTSD | |
| Hydrochloric Acid SCHEMBL5377286 | 0.83 | TLR8 (0.53) | TLR8TLR7 | |
| SCHEMBL5130313 | 0.83 | MLYCD (0.44) | DHODHHPGDTP53SMN1; SMN2CTSD | |
| SCHEMBL12497385 | 0.82 | HPGD (0.57) | HPGDGAAALDH1A1MAPTTP53 | |
| SCHEMBL3355469 | 0.82 | TP53 (0.41) | HPGDTP53CTSDBACE1GABRA1 | |
| SCHEMBL6889939 | 0.81 | CHEK2 (0.44) | HPGDALDH1A1MAPTTP53CTSD | |
| SCHEMBL6139506 | 0.80 | MLYCD (0.44) | HPGDTP53LMNASMN1; SMN2CTSD | |
| SCHEMBL2206850 | 0.80 | TP53 (0.51) | HPGDALDH1A1TP53BACE1GABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2004502669-A | — | — | 2004-01-29 | — | — | JP | claimed |
| EP-1353898-A2 | COMPOUNDS TO TREAT ALZHEIMER'S DISEASE | Elan Pharmaceuticals, Inc. (US) | 2003-10-22 | — | — | EP | claimed |
| WO-2002002512-A2 | COMPOUNDS TO TREAT ALZHEIMER'S DISEASE | ELAN PHARMACEUTICALS, INC. (US) | 2002-01-10 | — | — | WO | claimed |