Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 11/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.59 |
| ▸ | TSHR | P16473 | 7/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.58 |
| ▸ | USP2 | O75604 | 5/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | CASP1 | P29466 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11882343 | 0.80 | MGLL (0.72) | CYP3A4ALDH1A1SMN1; SMN2TSHRMAPK1 | |
| SCHEMBL26089744 | 0.80 | CYP3A4 (0.64) | CYP3A4ALDH1A1SMN1; SMN2TSHRMAPK1 | |
| SCHEMBL5101418 | 0.79 | KMT2A (0.82) | SMN1; SMN2TSHRTP53CYP1A2CYP2C19 | |
| SCHEMBL12745795 | 0.79 | POLB (0.46) | CYP3A4ALDH1A1SMN1; SMN2TSHRMAPK1 | |
| SCHEMBL9372725 | 0.79 | CYP3A4 (0.59) | CYP3A4ALDH1A1SMN1; SMN2TSHRMAPK1 | |
| SCHEMBL2081641 | 0.78 | MEN1 (0.66) | ALDH1A1SMN1; SMN2TSHRMAPK1CYP2C19 | |
| SCHEMBL13781697 | 0.78 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2TSHRMAPK1NPC1 | |
| SCHEMBL12769030 | 0.78 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2TSHRMAPK1TP53 | |
| SCHEMBL6764459 | 0.77 | ALDH1A1 (0.46) | ALDH1A1SMN1; SMN2TSHRMAPK1NPC1 | |
| SCHEMBL1578826 | 0.77 | ALDH1A1 (0.78) | CYP3A4ALDH1A1SMN1; SMN2TSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2403857-B1 | THIENOPYRIMIDINE AS CDC7 KINASE INHIBITORS | TAKEDA PHARMACEUTICAL (JP) | 2013-12-04 | — | — | EP | disclosed |
| US-20120040981-A1 | THIENOPYRIMIDINE AS CDC7 KINASE INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-02-16 | — | — | US | disclosed |
| EP-2403857-A1 | THIENOPYRIMIDINE AS CDC7 KINASE INHIBITORS | Takeda Pharmaceutical Company Limited (JP) | 2012-01-11 | — | — | EP | disclosed |
| WO-2010101302-A1 | THIENOPYRIMIDINE AS CDC7 KINASE INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120040981-A1 | THIENOPYRIMIDINE AS CDC7 KINASE INHIBITORS | CDC7, CDK7, DTYMK | CYP3A4 1840/4885ALDH1A1 1927/4885SMN1; SMN2 3772/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.