Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 5/20 | 0.70 |
| ▸ | AKR1C2 | P52895 | 4/20 | 0.70 |
| ▸ | MEN1 | O00255 | 3/20 | 0.70 |
| ▸ | AKR1B10 | O60218 | 3/20 | 0.70 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.70 |
| ▸ | AKR1C1 | Q04828 | 3/20 | 0.70 |
| ▸ | LMNA | P02545 | 2/20 | 0.70 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.70 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.70 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.70 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.70 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.70 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.70 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.70 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.70 |
| ▸ | DHFR | P00374 | 1/20 | 0.70 |
| ▸ | MPO | P05164 | 1/20 | 0.70 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11105154 | 0.93 | AKR1C3 (0.66) | AKR1C3AKR1C2MEN1AKR1B10PTGS2 | |
| SCHEMBL29834970 | 0.87 | AKR1C3 (0.77) | AKR1C3AKR1C2MEN1AKR1B10PTGS2 | |
| SCHEMBL1186480 | 0.87 | AKR1C3 (0.77) | AKR1C3AKR1C2MEN1AKR1B10PTGS2 | |
| SCHEMBL30320327 | 0.86 | FABP4 (0.80) | AKR1C3AKR1C2MEN1AKR1B10PTGS2 | |
| SCHEMBL355549 | 0.86 | FABP4 (0.80) | AKR1C3AKR1C2MEN1AKR1B10PTGS2 | |
| SCHEMBL6141201 | 0.84 | FABP4 (0.62) | AKR1C3AKR1C2MEN1AKR1B10PTGS2 | |
| SCHEMBL6142375 | 0.84 | FABP4 (0.84) | AKR1C3AKR1C2MEN1AKR1B10PTGS2 | |
| SCHEMBL9691899 | 0.84 | FABP4 (0.77) | AKR1C3AKR1C2MEN1AKR1B10PTGS2 | |
| SCHEMBL11794308 | 0.84 | AKR1C3 (0.63) | AKR1C3AKR1C2MEN1AKR1B10PTGS2 | |
| SCHEMBL14580629 | 0.83 | TAS2R14 (0.70) | AKR1C3AKR1C2MEN1AKR1B10PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1525183-A1 | INHIBITORS OF HCV NS5B POLYMERASE | Pharmacia & Upjohn Company LLC (US) | 2005-04-27 | — | — | EP | claimed |
| US-20040142993-A1 | Inhibitors of HCV NS5B polymerase | PHARMACIA & UPJOHN COMPANY | 2004-07-22 | — | — | US | claimed |
| WO-2004002940-A1 | INHIBITORS OF HCV NS5B POLYMERASE | PHARMACIA & UPJOHN COMPANY (US) | 2004-01-08 | — | — | WO | claimed |
| EP-1525183-A1 | INHIBITORS OF HCV NS5B POLYMERASE | Pharmacia & Upjohn Company LLC (US) | 2005-04-27 | — | — | EP | disclosed |
| US-20040142993-A1 | Inhibitors of HCV NS5B polymerase | PHARMACIA & UPJOHN COMPANY | 2004-07-22 | — | — | US | disclosed |
| WO-2004002940-A1 | INHIBITORS OF HCV NS5B POLYMERASE | PHARMACIA & UPJOHN COMPANY (US) | 2004-01-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040142993-A1 | Inhibitors of HCV NS5B polymerase | POLRMT, POLR1E, CTDSP1 | AKR1C3 2623/4885AKR1C2 2961/4885MEN1 4847/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.