Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 4/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.66 |
| ▸ | MAPT | P10636 | 3/20 | 0.66 |
| ▸ | MEN1 | O00255 | 2/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.66 |
| ▸ | GFER | P55789 | 1/20 | 0.66 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.66 |
| ▸ | KIF11 | P52732 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | TDO2 | P48775 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11390047 | 0.86 | ALDH1A1 (0.81) | GAAALDH1A1KDM4EMAPTMEN1 | |
| Hydrochloric Acid SCHEMBL10529934 | 0.81 | ALDH1A1 (0.73) | GAAALDH1A1KDM4EMAPTMEN1 | |
| SCHEMBL11397234 | 0.80 | MAPT (0.71) | GAAALDH1A1KDM4EMAPTMEN1 | |
| SCHEMBL2119044 | 0.79 | KIF11 (0.68) | KIF11TEAD1TEAD4TEAD2DHODH | |
| SCHEMBL25250382 | 0.77 | KDM4E (0.62) | GAAALDH1A1KDM4EMAPTMEN1 | |
| SCHEMBL6141228 | 0.77 | MAPK1 (0.70) | GAAALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL2276202 | 0.76 | ALDH1A1 (0.61) | GAAALDH1A1KDM4EMAPTMEN1 | |
| SCHEMBL16481206 | 0.74 | KIF11 (0.52) | KIF11TDO2RXFP1TAS2R14ABCB1 | |
| SCHEMBL5998737 | 0.74 | MAPT (0.62) | GAAALDH1A1KDM4EMAPTMEN1 | |
| SCHEMBL12407368 | 0.74 | KDM4E (0.71) | GAAALDH1A1KDM4EMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6930106-B2 | Inhibitors of HCV NS5B polymerase | PHARMACIA & UPJOHN COMPANY (US) | 2005-08-16 | — | — | US | disclosed |
| EP-1525186-A1 | INHIBITORS OF HCV NS5B POLYMERASE | Pharmacia & Upjohn Company LLC (US) | 2005-04-27 | — | — | EP | disclosed |
| US-20040142989-A1 | Inhibitors of HCV NS5B polymerase | PHARMACIA & UPJOHN COMPANY | 2004-07-22 | — | — | US | disclosed |
| WO-2004002944-A1 | INHIBITORS OF HCV NS5B POLYMERASE | PHARMACIA & UPJOHN COMPANY (US) | 2004-01-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040142989-A1 | Inhibitors of HCV NS5B polymerase | POLRMT, POLR1E, CTDSP1 | GAA 279/4885ALDH1A1 832/4885KDM4E 2739/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.