Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.56 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.56 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | LTA4H | P09960 | 2/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5048920 | 0.82 | HRH3 (0.59) | HRH3HRH4PDE1BPARP1ALDH1A1 | |
| SCHEMBL5047964 | 0.81 | HRH3 (0.57) | HRH3HRH4PARP1ALDH1A1LTA4H | |
| SCHEMBL16549263 | 0.73 | HRH3 (0.74) | HRH3HRH4PARP1ALDH1A1LTA4H | |
| SCHEMBL5697695 | 0.72 | HRH3 (0.46) | HRH3 | |
| SCHEMBL6142247 | 0.72 | PYCR1 (0.45) | ALDH1A1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL3130725 | 0.72 | KDM4E (0.72) | HRH3HRH4ALDH1A1LTA4HKDM4E | |
| SCHEMBL12082363 | 0.72 | HRH3 (0.77) | HRH3HRH4PARP1ALDH1A1LTA4H | |
| SCHEMBL19390961 | 0.71 | HRH3 (0.70) | HRH3HRH4PDE1BPARP1ALDH1A1 | |
| SCHEMBL3123680 | 0.70 | HRH3 (0.69) | HRH3HRH4PARP1ALDH1A1LTA4H | |
| SCHEMBL13649128 | 0.70 | HRH3 (0.74) | HRH3HRH4PARP1ALDH1A1LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1492785-A1 | NEW COMPOUNDS | AstraZeneca AB (SE) | 2005-01-05 | — | — | EP | claimed |
| WO-2003082853-A1 | NEW COMPOUNDS | ASTRAZENECA AB (SE) | 2003-10-09 | — | — | WO | claimed |
| EP-1492785-A1 | NEW COMPOUNDS | AstraZeneca AB (SE) | 2005-01-05 | — | — | EP | disclosed |
| WO-2003082853-A1 | NEW COMPOUNDS | ASTRAZENECA AB (SE) | 2003-10-09 | — | — | WO | disclosed |